{"id":"W2467627018","doi":"10.1200/jco.2007.25.18_suppl.5069","title":"A randomized phase II study of OGX-011 in combination with docetaxel and prednisone or docetaxel and prednisone alone in patients with metastatic hormone refractory prostate cancer (HRPC)","year":2007,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Clusterin in disease pathology","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Juravinski Cancer Centre; BC Cancer Agency","funders":"","keywords":"Medicine; Docetaxel; Clusterin; Prednisone; Internal medicine; Clinical endpoint; Urology; Oncology; Chemotherapy; Prostate cancer; Gastroenterology; Endocrinology; Cancer; Randomized controlled trial; Apoptosis; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002122313,0.002333591,0.003308821,0.0007025851,0.0005831284,0.001298701,0.001273399,0.002126747,0.008112624],"category_scores_gemma":[0.001818202,0.001325105,0.001699332,0.0006324463,0.002368772,0.001270978,0.0005771316,0.00396711,0.001579657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001159041,"about_ca_system_score_gemma":0.002375583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001405763,"about_ca_topic_score_gemma":0.003274554,"domain_scores_codex":[0.9991357,0.0004646618,0.00003610586,0.0001493062,0.0000608305,0.0001533839],"domain_scores_gemma":[0.9985398,0.0003262951,0.0002474117,0.0001420021,0.00008094993,0.0006636238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9566174,0.02808804,0.000608091,0.0002385988,0.0002953154,0.00004041165,0.00006562625,0.0003929719,0.003560933,0.0001057627,0.0005756741,0.009411241],"study_design_scores_gemma":[0.8253927,0.1724637,0.001011351,0.000008960888,0.0001255486,0.00002279042,0.00001944039,0.0002425663,0.0002540481,0.00007822698,0.0003687227,0.00001182106],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854202,0.001258738,0.0006022927,0.0006000533,0.0005577446,0.008861547,0.0008752274,0.0001140708,0.00171014],"genre_scores_gemma":[0.9770665,0.00167518,0.001927144,0.001428165,0.0005914517,0.01124257,0.001416862,0.00003506045,0.004617067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008112624,"threshold_uncertainty_score":0.02713948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06795530814746775,"score_gpt":0.4490117613801098,"score_spread":0.3810564532326421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}