{"id":"W2467821377","doi":"10.2337/db16-0058","title":"The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels","year":2016,"lang":"en","type":"article","venue":"Diabetes","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":386,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; British Heart Foundation; Wellcome Trust; Merck KGaA; Wellcome; GlaxoSmithKline; AstraZeneca; Canadian Diabetes Association; Pfizer","keywords":"Canagliflozin; AMPK; Empagliflozin; Dapagliflozin; Phlorizin; Endocrinology; Chemistry; Internal medicine; Pharmacology; Type 2 diabetes; Protein kinase A; Phosphorylation; Glucose transporter; Biochemistry; Diabetes mellitus; Medicine; Insulin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001414885,0.0002612626,0.0003551021,0.0003421621,0.0001205885,0.0003578446,0.0001579007,0.0002584617,0.001005104],"category_scores_gemma":[0.0001517687,0.0001278931,0.0002457534,0.0002564995,0.000157686,0.0001967713,0.0001211671,0.0005023073,0.0002377169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004096573,"about_ca_system_score_gemma":0.0001890064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000845216,"about_ca_topic_score_gemma":0.001598551,"domain_scores_codex":[0.9998815,0.00001600628,0.00001318773,0.00002456423,0.0000401984,0.00002445566],"domain_scores_gemma":[0.9999486,0.00000973156,0.00001563541,0.000006369277,0.00000905149,0.00001059939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0017582,0.0003587235,0.001872852,0.000527021,0.0001218912,0.0001258555,0.00002897339,0.0005882307,0.9489509,0.0005976786,0.001009741,0.04405993],"study_design_scores_gemma":[0.0008170372,0.003084604,0.02276479,0.00005396705,0.0002880581,0.0008075532,0.00003984309,0.004249769,0.9345683,0.0004858374,0.03280931,0.00003082693],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9540673,0.02559417,0.007468282,0.001223087,0.0004432411,0.0001018913,0.0005075706,0.0002686271,0.01032589],"genre_scores_gemma":[0.9850296,0.00774012,0.003824378,0.000405857,0.00009634839,0.00005214318,0.0004814728,0.00001372694,0.00235622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001005104,"threshold_uncertainty_score":0.003362417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007322274669388178,"score_gpt":0.2032622541656051,"score_spread":0.1959399794962169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}