{"id":"W2467994580","doi":"10.1016/j.celrep.2016.06.001","title":"Notch Signaling Rescues Loss of Satellite Cells Lacking Pax7 and Promotes Brown Adipogenic Differentiation","year":2016,"lang":"en","type":"article","venue":"Cell Reports","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health; Canada Research Chairs; Ontario Ministry of Economic Development and Innovation; Canadian Institutes of Health Research; University of Ottawa","keywords":"MyoD; Adipogenesis; Myogenesis; Cell biology; HES1; Ectopic expression; Transcription factor; MyoD Protein; Biology; Notch signaling pathway; Downregulation and upregulation; Cellular differentiation; Chemistry; Myocyte; Signal transduction; Cell culture; Mesenchymal stem cell; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000124777,0.0001022493,0.0001224243,0.00002345234,0.00004135428,0.000006329199,0.00004346462,0.0001147371,0.00002526497],"category_scores_gemma":[0.00004032334,0.00007514888,0.00005814331,0.00002861414,0.00008744928,0.000004538957,0.00005337647,0.00003008255,0.00000147562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003349378,"about_ca_system_score_gemma":0.00002614649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009857699,"about_ca_topic_score_gemma":0.000007833381,"domain_scores_codex":[0.999216,0.0000401788,0.0002398614,0.0002908046,0.00006564276,0.0001475658],"domain_scores_gemma":[0.9994543,0.00002008048,0.0001891884,0.0002395961,0.00005364952,0.00004316986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003929602,0.00003614782,0.02242406,0.0000508294,0.00002260877,0.000007269137,0.00004420554,0.000002453381,0.9744851,0.00000527061,0.00003988789,0.002842874],"study_design_scores_gemma":[0.0001794666,0.00009296873,0.01342416,0.00003115883,0.00002104977,0.000009320823,0.0000134393,0.000001792275,0.984543,0.0004869328,0.001087824,0.0001088657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996976,0.002007659,0.0003503343,0.0000259482,0.00009492013,0.0001063618,0.000002670822,0.00000795617,0.0004281395],"genre_scores_gemma":[0.9988008,0.0006097255,0.0001065018,0.00002488034,0.00005105228,0.000005309146,0.0000275193,0.00001218418,0.0003620143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01005792,"threshold_uncertainty_score":0.3064483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007290267791579051,"score_gpt":0.2136990587784767,"score_spread":0.2064087909868976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}