{"id":"W2468099764","doi":"10.1212/wnl.86.16_supplement.s49.008","title":"Effect of Ocrelizumab on Disability Progression in Patients with Relapsing Multiple Sclerosis: Analysis of the Phase III, Double-Blind, Double-Dummy, Interferon Beta-1a-Controlled OPERA I and OPERA II Studies (S49.008)","year":2016,"lang":"en","type":"article","venue":"Neurology","topic":"vaccines and immunoinformatics approaches","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Montreal Neurological Institute and Hospital","funders":"","keywords":"Ocrelizumab; Medicine; Multiple sclerosis; Double blind; Opera; Interferon beta-1a; Relapsing remitting; Interferon beta; Dermatology; Internal medicine; Art; Alternative medicine; Art history; Psychiatry; Placebo; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004466952,0.001667763,0.002995303,0.0004393551,0.0003534374,0.001069676,0.0007507388,0.001409489,0.002303323],"category_scores_gemma":[0.002883665,0.0005803513,0.002655689,0.0004277574,0.001090481,0.000862907,0.0004043217,0.002954216,0.0004267413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007228574,"about_ca_system_score_gemma":0.001207836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006003341,"about_ca_topic_score_gemma":0.001072009,"domain_scores_codex":[0.9985341,0.0009026385,0.0001082698,0.0002066072,0.0001065819,0.0001417524],"domain_scores_gemma":[0.9970556,0.001010032,0.0008140148,0.0002269841,0.0001528192,0.0007403882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9597871,0.007729334,0.00159395,0.0005303402,0.001228033,0.00003292447,0.00005481169,0.000328994,0.004826271,0.00004529542,0.0003177825,0.02352513],"study_design_scores_gemma":[0.7275764,0.2614611,0.00774138,0.00004615177,0.0009080066,0.00006668692,0.0000221255,0.0004158761,0.001115612,0.00007430211,0.000550365,0.00002193708],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915154,0.005618806,0.0003649151,0.0002683092,0.000164946,0.0007824707,0.0005142479,0.00004499713,0.0007258789],"genre_scores_gemma":[0.9944451,0.002003091,0.000741893,0.0003864883,0.0002537477,0.0007769542,0.0007132443,0.00001351333,0.0006660486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004466952,"threshold_uncertainty_score":0.02362376,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02517918105396329,"score_gpt":0.2884214249727736,"score_spread":0.2632422439188103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}