{"id":"W2468101570","doi":"10.1096/fj.201600356r","title":"IFN regulatory factor 1 restricts hepatitis E virus replication by activating STAT1 to induce antiviral IFN‐stimulated genes","year":2016,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Hepatitis Viruses Studies and Epidemiology","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Vector Institute; European Association for the Study of the Liver; Maag Lever Darm Stichting; China Scholarship Council; Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"IRF1; STAT1; Interferon regulatory factors; Biology; Transcription factor; Viral replication; Virology; Interferon; Gene silencing; Chromatin immunoprecipitation; Cell biology; Gene; Promoter; Virus; Gene expression; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007246285,0.0002108409,0.0004155001,0.0001057792,0.0004513237,0.00002689103,0.0001955053,0.0001256389,0.000149998],"category_scores_gemma":[0.001863985,0.0001152703,0.0001088541,0.0002327104,0.0001065635,0.0001675627,0.0001023075,0.0003564384,0.00009731115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003649252,"about_ca_system_score_gemma":0.0001715216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001761761,"about_ca_topic_score_gemma":0.0002374515,"domain_scores_codex":[0.9979604,0.000310007,0.0005825774,0.0003322896,0.000312047,0.0005026183],"domain_scores_gemma":[0.9981046,0.0005177722,0.0003549847,0.000565504,0.0002008715,0.0002562709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001504237,0.00003857068,0.2046877,0.000006121896,0.0001082108,0.00002486697,0.0002977021,0.000005719309,0.6862762,0.00001694067,0.01952471,0.08886281],"study_design_scores_gemma":[0.001426804,0.000796181,0.6810997,0.0003059419,0.0000703806,0.0002266568,0.00008022149,0.0001361485,0.2962822,0.0001792437,0.01909751,0.000299056],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905536,0.0004007751,0.002065775,0.005921772,0.0003221579,0.0003022456,0.0000906534,0.00006008046,0.0002829237],"genre_scores_gemma":[0.9923129,0.003966945,0.0004559579,0.001893234,0.0005409634,0.00001346256,0.000008341973,0.00003599373,0.0007722178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.476412,"threshold_uncertainty_score":0.4700586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05256307252814565,"score_gpt":0.3194348355988563,"score_spread":0.2668717630707106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}