{"id":"W2468101570","doi":"10.1096/fj.201600356r","title":"IFN regulatory factor 1 restricts hepatitis E virus replication by activating STAT1 to induce antiviral IFN‐stimulated genes","year":2016,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Hepatitis Viruses Studies and Epidemiology","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Vector Institute; European Association for the Study of the Liver; Maag Lever Darm Stichting; China Scholarship Council; Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"IRF1; STAT1; Interferon regulatory factors; Biology; Transcription factor; Viral replication; Virology; Interferon; Gene silencing; Chromatin immunoprecipitation; Cell biology; Gene; Promoter; Virus; Gene expression; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001673407,0.0003455211,0.0002634256,0.0002254965,0.0002065386,0.0002722893,0.0001867453,0.0002192645,0.002811532],"category_scores_gemma":[0.00007277205,0.0001640998,0.0004165981,0.00009954855,0.000192979,0.0002297215,0.0001890482,0.0007565367,0.000861189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002931248,"about_ca_system_score_gemma":0.0002697362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002608116,"about_ca_topic_score_gemma":0.000566627,"domain_scores_codex":[0.999863,0.00001774252,0.00001067648,0.00002966687,0.00003455338,0.00004429149],"domain_scores_gemma":[0.9999624,0.000006285268,0.000009095399,0.000004813056,0.000006469496,0.00001091498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001024397,0.00004142532,0.0002124745,0.00006705127,0.00000400466,0.00002218753,0.00001096358,0.00007539259,0.9967611,0.0001307673,0.0001527804,0.002419345],"study_design_scores_gemma":[0.0000511109,0.0003776852,0.004945294,0.00001772407,0.00002419245,0.00019487,0.00004113535,0.002951988,0.9828143,0.0001633307,0.008410435,0.00000808422],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9728103,0.008892268,0.009069595,0.0004627906,0.0002292736,0.00007711525,0.001136182,0.0003576764,0.00696482],"genre_scores_gemma":[0.9885001,0.002212042,0.00289292,0.0001992315,0.00003079,0.00004623476,0.001064538,0.00003214445,0.005022026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002811532,"threshold_uncertainty_score":0.009405494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05256307252814565,"score_gpt":0.3194348355988563,"score_spread":0.2668717630707106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}