{"id":"W2468182232","doi":"10.1182/blood.v124.21.237.237","title":"Administration of Dexamethasone during Initial Exposure to Factor VIII Prevents the Development of Anti-Factor VIII Antibodies and Increases the Proportion of Thymic but Not Splenic Regulatory T Cells in the Exon 16 Knockout C57Bl6 Hemophilia Α Mouse Model","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Janeway Children's Health and Rehabilitation Centre; Memorial University of Newfoundland; Queen's University","funders":"","keywords":"Medicine; Immunology; FOXP3; Antibody; Dexamethasone; Spleen; Immune system; Immune tolerance; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002147055,0.0007888543,0.0005319889,0.0006487342,0.000176777,0.0003775807,0.0004507665,0.0006870175,0.002809322],"category_scores_gemma":[0.0001409821,0.0003000243,0.0004870827,0.0002242718,0.0004941042,0.0003228727,0.0001961769,0.002245798,0.0008586539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002895065,"about_ca_system_score_gemma":0.0002766359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000570936,"about_ca_topic_score_gemma":0.0008663726,"domain_scores_codex":[0.9996113,0.00003803181,0.00004081261,0.0001072328,0.0001155585,0.0000871287],"domain_scores_gemma":[0.999438,0.00003550443,0.0002094295,0.00005093046,0.00003175902,0.0002342969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001238401,0.0004492439,0.0002449911,0.00006234568,0.00001164591,0.0001166408,0.00002796249,0.00006541009,0.9960885,0.0000577568,0.0001065366,0.001530556],"study_design_scores_gemma":[0.0002492068,0.004602056,0.005330168,0.00003254487,0.00005850523,0.0006633843,0.0000793459,0.0005614148,0.9847356,0.00006862522,0.003603428,0.00001575761],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929421,0.001531652,0.002214214,0.0002256237,0.0001480148,0.00009280921,0.001020329,0.0002512448,0.001574111],"genre_scores_gemma":[0.9833986,0.001320956,0.003440022,0.0001866963,0.00004823961,0.0002277128,0.001195101,0.0000959027,0.0100868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002809322,"threshold_uncertainty_score":0.009398103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03406419501503574,"score_gpt":0.2953710301147141,"score_spread":0.2613068350996783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}