{"id":"W2468330779","doi":"10.18632/oncotarget.10342","title":"β-cell insulin receptor deficiency during<i>in utero</i>development induces an islet compensatory overgrowth response","year":2016,"lang":"en","type":"article","venue":"Oncotarget","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Western University","funders":"","keywords":"Endocrinology; Internal medicine; Islet; Biology; Autocrine signalling; Paracrine signalling; Pancreas; PDX1; Proinsulin; Insulin; Beta cell; Neogenesis; Cell growth; Receptor; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001958826,0.0003290667,0.0003174667,0.0002189787,0.0001455863,0.00050228,0.0002779613,0.0003477374,0.001873839],"category_scores_gemma":[0.0002163837,0.0002704521,0.0003275668,0.0000862987,0.0004047332,0.00026815,0.0002891476,0.001183296,0.0005925134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003490114,"about_ca_system_score_gemma":0.0002555691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003606189,"about_ca_topic_score_gemma":0.0007338602,"domain_scores_codex":[0.9998139,0.00002403084,0.00001940121,0.00005122503,0.0000378338,0.0000536545],"domain_scores_gemma":[0.9995638,0.00006103872,0.0002135251,0.00003509601,0.00001742989,0.0001091423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003517099,0.0000441915,0.001717223,0.00004681511,0.000009859433,0.0005872843,0.00003544023,0.00004062154,0.9951866,0.0002472029,0.0001810349,0.001552062],"study_design_scores_gemma":[0.00005386269,0.0008085843,0.05150264,0.00005938319,0.00006471114,0.003221455,0.0003683672,0.0006015425,0.9366323,0.000283966,0.006383245,0.00001995706],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919088,0.001688306,0.002340468,0.0002827634,0.00008297261,0.00003749095,0.0004682814,0.000149974,0.003040829],"genre_scores_gemma":[0.9918306,0.001206896,0.001475366,0.0002903485,0.00003354863,0.0000645921,0.0005516229,0.0000796683,0.004467238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001873839,"threshold_uncertainty_score":0.00626868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01357894940914921,"score_gpt":0.2439436742091332,"score_spread":0.230364724799984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}