{"id":"W2468518687","doi":"10.4049/jimmunol.1600253","title":"Osteoclast-Primed Foxp3+ CD8 T Cells Induce T-bet, Eomesodermin, and IFN-γ To Regulate Bone Resorption","year":2016,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; University of British Columbia","keywords":"Osteoclast; Cell biology; Bone resorption; FOXP3; Osteoimmunology; Cytotoxic T cell; Chemistry; IL-2 receptor; CD8; T cell; Immune system; Immunology; Activator (genetics); Biology; Receptor; Endocrinology; RANKL; In vitro; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001872108,0.0006237095,0.0003734754,0.0004224968,0.000167678,0.0003662254,0.0002452039,0.0003630515,0.002780145],"category_scores_gemma":[0.0001218814,0.0002833412,0.000380379,0.0001941491,0.0003716681,0.0002134621,0.0003034622,0.001732076,0.0005857947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002806208,"about_ca_system_score_gemma":0.0002871967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002872419,"about_ca_topic_score_gemma":0.000712088,"domain_scores_codex":[0.9996408,0.00002930483,0.0000345373,0.00008172332,0.00008295456,0.0001306336],"domain_scores_gemma":[0.999793,0.00002302543,0.00007505489,0.0000222179,0.00001699073,0.00006969662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009108187,0.00003467218,0.00009262408,0.00002653616,0.000002582668,0.0000351779,0.00001006848,0.00003355041,0.9989251,0.00007174089,0.00002074406,0.0006559055],"study_design_scores_gemma":[0.0001166601,0.0003539327,0.002303587,0.00001077068,0.00001950093,0.0002562068,0.00002776788,0.0005953822,0.9933407,0.0001052701,0.002865729,0.000004451775],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901338,0.001137092,0.004802846,0.0001450826,0.00009528671,0.0001078886,0.0005185407,0.0002575667,0.002801829],"genre_scores_gemma":[0.9891683,0.0005785378,0.003526414,0.0001569262,0.00003835046,0.0001117941,0.0007127915,0.00006696073,0.005640032],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002780145,"threshold_uncertainty_score":0.00930047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006902624416852351,"score_gpt":0.2192110775117622,"score_spread":0.2123084530949099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}