{"id":"W2468556937","doi":"10.1038/srep28423","title":"Trehalose, sucrose and raffinose are novel activators of autophagy in human keratinocytes through an mTOR-independent pathway","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Ontario Institute for Cancer Research","funders":"Peking Union Medical College; Fundamental Research Funds for the Central Universities; Natural Science Foundation of Jiangsu Province; Government of Jiangsu Province; Ministry of Education of the People's Republic of China; National Natural Science Foundation of China","keywords":"Raffinose; Trehalose; Autophagy; PI3K/AKT/mTOR pathway; Cell biology; Sucrose; Chemistry; Biochemistry; Biology; Signal transduction; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006495682,0.0002087387,0.0004186583,0.0001919288,0.0001668104,0.00006393152,0.00009513123,0.0001213931,0.0002394061],"category_scores_gemma":[0.0001195946,0.0001405316,0.00009765607,0.0002898242,0.0004114176,0.000513914,0.0000620089,0.0001040243,0.000003488504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007738048,"about_ca_system_score_gemma":0.0002334168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007455859,"about_ca_topic_score_gemma":0.00005727547,"domain_scores_codex":[0.997642,0.00004682982,0.0006432578,0.0007988641,0.0005444561,0.0003246072],"domain_scores_gemma":[0.9982465,0.00004295388,0.0004357655,0.0009299508,0.0001403949,0.0002044608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007961306,0.0008876074,0.07833849,0.00005413739,0.0000375629,0.001017476,0.0009432249,0.00000166931,0.9143605,0.0005495945,0.0002396136,0.003490475],"study_design_scores_gemma":[0.001640165,0.0001614352,0.2464803,0.000248513,0.00002293101,0.0001902714,0.0002153207,0.000008338969,0.7466238,0.002337519,0.00189629,0.0001750847],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975345,0.0003673384,0.0000458011,0.00008922897,0.0009452681,0.0004218231,0.00001573572,0.00006346739,0.000516874],"genre_scores_gemma":[0.9976707,0.00001533316,0.0002016746,0.00004891498,0.00007870423,0.00002333219,0.00002612383,0.00002531568,0.001909955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1681419,"threshold_uncertainty_score":0.5730712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02403538361221876,"score_gpt":0.2948850222143432,"score_spread":0.2708496386021244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}