{"id":"W2468828262","doi":"10.1074/jbc.m116.731745","title":"Activities of the Cytoplasmic Domains of Patched-1 Modulate but Are Not Essential for the Regulation of Canonical Hedgehog Signaling","year":2016,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Hedgehog; Patched; PTCH1; Cell biology; Smoothened; Biology; Transmembrane protein; Hedgehog signaling pathway; Transmembrane domain; Signal transduction; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008959856,0.0002054989,0.0001393583,0.00009133221,0.0001303739,0.0001955516,0.0001666121,0.0001507838,0.0008330334],"category_scores_gemma":[0.0001265623,0.0001165891,0.0001143472,0.00007536505,0.0002262373,0.000166584,0.0001859885,0.0003566874,0.0003599668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003035875,"about_ca_system_score_gemma":0.000164175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002729154,"about_ca_topic_score_gemma":0.0005472808,"domain_scores_codex":[0.9998776,0.00001607078,0.000007531432,0.0000298934,0.00004019555,0.00002873047],"domain_scores_gemma":[0.9999062,0.00001596303,0.00002889355,0.00001139,0.000007873898,0.00002971504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006950075,0.000008360154,0.0001903564,0.00001739153,0.000002121203,0.00003129992,0.000003178781,0.00002217451,0.9990945,0.0001049626,0.00001717559,0.0004389586],"study_design_scores_gemma":[0.0000272338,0.0001166366,0.01638915,0.000005120438,0.00001962642,0.0005671491,0.00002056378,0.001105979,0.9769651,0.000101552,0.004678079,0.000003821421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995949,0.001411691,0.001264024,0.00008299447,0.00002566756,0.000007569928,0.0001692664,0.00002601755,0.001063835],"genre_scores_gemma":[0.9971324,0.0004103127,0.0007305772,0.00002405024,0.000008744076,0.00001043111,0.0004785867,0.000008353624,0.001196568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008330334,"threshold_uncertainty_score":0.002786756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02371774531912479,"score_gpt":0.2529791289253811,"score_spread":0.2292613836062563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}