{"id":"W2468854408","doi":"10.1128/aac.00661-16","title":"The Heterodimeric ABC Transporter EfrCD Mediates Multidrug Efflux in Enterococcus faecalis","year":2016,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Government of Canada","keywords":"Efflux; Enterococcus faecalis; ATP-binding cassette transporter; Multiple drug resistance; Enterococcus; Microbiology; Biology; Transporter; Computational biology; Antibiotics; Genetics; Bacteria; Gene; Staphylococcus aureus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002212606,0.0002028919,0.000278093,0.0001878787,0.0001228126,0.0003340973,0.0001145468,0.0002348217,0.0004144163],"category_scores_gemma":[0.0002707364,0.00007784156,0.0001607954,0.0001864265,0.0001155349,0.0001859436,0.0002406562,0.0002154345,0.0002772585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002569729,"about_ca_system_score_gemma":0.0001575384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000876697,"about_ca_topic_score_gemma":0.0007780478,"domain_scores_codex":[0.9997798,0.00007091906,0.00002642168,0.00003382131,0.00006050423,0.0000284507],"domain_scores_gemma":[0.9999132,0.000019348,0.00001959232,0.00001288422,0.00002060267,0.00001432628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000566216,0.00002860547,0.003207366,0.0000361881,0.000005183801,0.00008645224,0.00001704202,0.00007913121,0.9934561,0.00007771651,0.00005940258,0.002890209],"study_design_scores_gemma":[0.00002422363,0.0002833477,0.04209151,0.00001901576,0.00003579335,0.001815831,0.0003166105,0.006675811,0.9409991,0.0001564357,0.007565279,0.0000170046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947836,0.0009803058,0.003102159,0.0001165261,0.000009886221,0.000009969967,0.0002128159,0.00004024635,0.0007444497],"genre_scores_gemma":[0.9955353,0.0003672261,0.002892278,0.00004368,0.000002361076,0.000007809287,0.0003831258,0.000009154429,0.0007592111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000876697,"threshold_uncertainty_score":0.001864433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005400339333861635,"score_gpt":0.2274517985514079,"score_spread":0.2220514592175462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}