{"id":"W2468923610","doi":"10.1098/rsob.160122","title":"CCL5 activation of CCR5 regulates cell metabolism to enhance proliferation of breast cancer cells","year":2016,"lang":"en","type":"article","venue":"Open Biology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"CCL5; GLUT1; Glucose transporter; Biology; Glucose uptake; Glucose Transporter Type 1; Cell growth; Glycolysis; Cancer research; Cancer cell; Tumor microenvironment; Cell biology; Cancer; Metabolism; Endocrinology; Biochemistry; Cytotoxic T cell; Insulin; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001728172,0.000130555,0.0002823053,0.00004779323,0.00002966711,0.000007738631,0.0003137386,0.0001611313,0.0001155197],"category_scores_gemma":[0.00002683222,0.00009333636,0.000059006,0.00009823832,0.00008311241,0.0000123507,0.0001811998,0.00003048518,0.00000628201],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001090083,"about_ca_system_score_gemma":0.0001357263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003075561,"about_ca_topic_score_gemma":0.0000927307,"domain_scores_codex":[0.9990474,0.00008135702,0.0002780968,0.0003439657,0.0000588003,0.0001903554],"domain_scores_gemma":[0.9991602,0.00001488971,0.0002186515,0.0003319465,0.0002148671,0.00005948297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002943413,0.00005993458,0.0003304115,0.00001466397,0.00003130878,1.976547e-8,0.000044039,0.000009709662,0.9680431,0.000170533,0.002350388,0.02865151],"study_design_scores_gemma":[0.0004523478,0.00009881079,0.004528256,0.00002291209,0.00001799091,0.000001145529,0.00001084347,0.000001141731,0.8964645,0.00009370525,0.09818903,0.0001193709],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952099,0.0007410114,0.001285777,0.0006506267,0.0006204333,0.0005011957,0.0002642407,0.000004085463,0.0007227724],"genre_scores_gemma":[0.9950783,0.001114056,0.0009326309,0.0002251175,0.0005991549,0.00008969954,0.00004029892,0.00001587793,0.00190487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09583864,"threshold_uncertainty_score":0.3806146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008034034152477608,"score_gpt":0.2821420919317245,"score_spread":0.2741080577792469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}