{"id":"W2468950574","doi":"10.1038/mto.2016.17","title":"Systemically administered AAV9-sTRAIL combats invasive glioblastoma in a patient-derived orthotopic xenograft model","year":2016,"lang":"en","type":"article","venue":"Molecular Therapy — Oncolytics","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke","keywords":"Genetic enhancement; Cancer research; Adeno-associated virus; Brain tumor; Biology; Reporter gene; Systemic administration; Transgene; Viral vector; Gene delivery; Vector (molecular biology); Immunology; Pathology; Molecular biology; Gene; Gene expression; Medicine; In vivo; Recombinant DNA","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003002346,0.0004557385,0.0004441342,0.0001954422,0.00008418525,0.00005829161,0.0006393932,0.0003988997,0.00003978271],"category_scores_gemma":[0.0001220773,0.0003688565,0.0002516973,0.0002857918,0.0002165916,0.00001233938,0.0001953975,0.0002103902,0.00004259469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001453463,"about_ca_system_score_gemma":0.0006679253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008965772,"about_ca_topic_score_gemma":0.0003227484,"domain_scores_codex":[0.9968892,0.0003640755,0.0006326996,0.0007928145,0.0005400903,0.000781112],"domain_scores_gemma":[0.9981538,0.00004978892,0.0002020266,0.001067639,0.0002392844,0.0002874606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003866401,0.0003124962,0.0003510878,0.00003697722,0.0001453125,0.000182234,0.0001904497,0.0002743335,0.9823467,0.00003522689,0.000122429,0.01213632],"study_design_scores_gemma":[0.004762014,0.007747246,0.00007396526,0.0001730381,0.0000118088,0.00004214673,0.00007222409,0.0004038191,0.9846796,0.0002293433,0.001278984,0.0005258548],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939027,0.001216842,0.002792477,0.0004624542,0.0001040521,0.001156764,0.00005880401,0.00004387154,0.000262008],"genre_scores_gemma":[0.9963732,0.0008328081,0.0006773701,0.001318425,0.00006873003,0.0002279562,0.00003501774,0.0001193007,0.0003471927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01161046,"threshold_uncertainty_score":0.9998763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02111430748725016,"score_gpt":0.2848859474876812,"score_spread":0.2637716400004311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}