{"id":"W2468950574","doi":"10.1038/mto.2016.17","title":"Systemically administered AAV9-sTRAIL combats invasive glioblastoma in a patient-derived orthotopic xenograft model","year":2016,"lang":"en","type":"article","venue":"Molecular Therapy — Oncolytics","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke","keywords":"Genetic enhancement; Cancer research; Adeno-associated virus; Brain tumor; Biology; Reporter gene; Systemic administration; Transgene; Viral vector; Gene delivery; Vector (molecular biology); Immunology; Pathology; Molecular biology; Gene; Gene expression; Medicine; In vivo; Recombinant DNA","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001724283,0.0004757568,0.0005488942,0.0002408364,0.0001096594,0.000307317,0.0001599918,0.0002444187,0.0009287901],"category_scores_gemma":[0.00006322895,0.0001352605,0.0002419478,0.0001443694,0.0001664671,0.0002068048,0.0001346907,0.0006818813,0.0002648336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002225438,"about_ca_system_score_gemma":0.0003743148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001511262,"about_ca_topic_score_gemma":0.002728311,"domain_scores_codex":[0.9998962,0.00001382617,0.000007787996,0.00002647708,0.00002832109,0.00002744851],"domain_scores_gemma":[0.9999429,0.00000617818,0.00001747498,0.000008746982,0.000008597151,0.00001605273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001780705,0.0002208338,0.0002694275,0.00004254681,0.00001256518,0.00007437943,0.00003451844,0.0001729786,0.9952833,0.0001038791,0.0001401314,0.003467281],"study_design_scores_gemma":[0.00006332227,0.006297471,0.004116901,0.00001156159,0.00006940299,0.0008016637,0.00007508592,0.00296427,0.9817346,0.00007098477,0.003784857,0.000009844649],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926051,0.0009969485,0.00450478,0.00009139562,0.00004802493,0.00007260992,0.0002023086,0.0002217256,0.001257136],"genre_scores_gemma":[0.9922902,0.001183039,0.003222294,0.00003340343,0.00001218735,0.00006104599,0.000409642,0.00004040786,0.002747793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001511262,"threshold_uncertainty_score":0.003107131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02111430748725016,"score_gpt":0.2848859474876812,"score_spread":0.2637716400004311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}