{"id":"W2469000447","doi":"10.1093/jnci/djw111","title":"RE: RNA Disruption Assay as a Biomarker of Pathological Complete Response in Neoadjuvant Trastuzumab-Treated Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer","year":2016,"lang":"en","type":"letter","venue":"JNCI Journal of the National Cancer Institute","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Science Foundation Ireland; Irish Cancer Society; Health Research Board; GlaxoSmithKline","keywords":"Trastuzumab; Human Epidermal Growth Factor Receptor 2; Breast cancer; Oncology; Biomarker; Epidermal growth factor receptor; Medicine; Pathological; Cancer research; Internal medicine; Cancer; Neoadjuvant therapy; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001006152,0.0004809872,0.0006023578,0.0005658207,0.0007001568,0.001140198,0.0007418267,0.008021675,0.002242972],"category_scores_gemma":[0.01025752,0.0002869318,0.0003699132,0.0003356228,0.0007370154,0.0006838093,0.0002702776,0.005866262,0.003084003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001450408,"about_ca_system_score_gemma":0.0007682132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001137672,"about_ca_topic_score_gemma":0.002047108,"domain_scores_codex":[0.9990342,0.000286428,0.0001687697,0.0001133672,0.0002731344,0.0001242346],"domain_scores_gemma":[0.9974299,0.001352844,0.0001936685,0.0001168894,0.0005917948,0.0003149344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00129254,0.0002968663,0.03676892,0.0002148323,0.00008361586,0.06488249,0.0004609283,0.0004285057,0.01538908,0.002676023,0.7831946,0.09431164],"study_design_scores_gemma":[0.0005152245,0.001699538,0.0492381,0.0006980299,0.0003409897,0.1564332,0.001423969,0.008561513,0.0314949,0.009474653,0.7399325,0.0001874039],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.04452365,0.005644203,0.001927164,0.8699005,0.04613115,0.0001182109,0.0005169981,0.0003907018,0.03084735],"genre_scores_gemma":[0.3182273,0.004578943,0.003964692,0.5538208,0.0663276,0.0002041832,0.0005503114,0.0001808354,0.05214529],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.008021675,"threshold_uncertainty_score":0.0105235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.122928345700168,"score_gpt":0.4129859527930205,"score_spread":0.2900576070928524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}