{"id":"W2469051128","doi":"10.1200/jco.2015.33.18_suppl.lba7005","title":"Ibrutinib combined with bendamustine and rituximab (BR) in previously treated chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL): First results from a randomized, double-blind, placebo-controlled, phase III study.","year":2015,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Medicine; Bendamustine; Ibrutinib; Internal medicine; Clinical endpoint; Rituximab; Chronic lymphocytic leukemia; Gastroenterology; Interim analysis; Progression-free survival; Neutropenia; Placebo; Phases of clinical research; Refractory (planetary science); Surgery; Randomized controlled trial; Lymphoma; Chemotherapy; Leukemia; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.02025657,0.0009645094,0.01133642,0.0009222619,0.000162552,0.0001243079,0.0008333696,0.001180128,0.00008671908],"category_scores_gemma":[0.01652396,0.000632597,0.001007526,0.0009725812,0.00153539,0.0003641927,0.0004090511,0.001498607,0.00006597004],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.110483,"about_ca_system_score_gemma":0.1925325,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01238644,"about_ca_topic_score_gemma":0.008579248,"domain_scores_codex":[0.9830502,0.002914036,0.009444287,0.001316581,0.001844337,0.001430606],"domain_scores_gemma":[0.9699333,0.02017793,0.004840161,0.001168852,0.001535743,0.00234397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.962166,0.007546034,0.0004765839,0.0001243167,0.003412274,0.0133173,0.00153546,0.001346501,0.00001024452,0.00002552296,0.0008761676,0.009163601],"study_design_scores_gemma":[0.8554317,0.05849979,0.0001761972,0.000942875,0.003914325,0.003154429,0.0008175948,0.07498184,0.00005143302,0.00007287004,0.001448995,0.0005079525],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839545,0.003338218,0.00007153575,0.001209887,0.000751827,0.008234925,0.00002621859,0.00008359012,0.002329305],"genre_scores_gemma":[0.9935818,0.001905287,0.0009669259,0.0004755577,0.001642443,0.00033545,0.00006934316,0.0001319127,0.0008912691],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1067343,"threshold_uncertainty_score":0.9996125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1231435997574777,"score_gpt":0.4210088676329488,"score_spread":0.2978652678754711,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}