{"id":"W2469051128","doi":"10.1200/jco.2015.33.18_suppl.lba7005","title":"Ibrutinib combined with bendamustine and rituximab (BR) in previously treated chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL): First results from a randomized, double-blind, placebo-controlled, phase III study.","year":2015,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Medicine; Bendamustine; Ibrutinib; Internal medicine; Clinical endpoint; Rituximab; Chronic lymphocytic leukemia; Gastroenterology; Interim analysis; Progression-free survival; Neutropenia; Placebo; Phases of clinical research; Refractory (planetary science); Surgery; Randomized controlled trial; Lymphoma; Chemotherapy; Leukemia; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002677147,0.001299519,0.002526155,0.0007940555,0.0004150916,0.001010057,0.001210022,0.001492865,0.003664959],"category_scores_gemma":[0.001204425,0.0008885306,0.001318988,0.0006136347,0.001001636,0.001067835,0.0005062632,0.002727481,0.0009014928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008045964,"about_ca_system_score_gemma":0.00112763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007807546,"about_ca_topic_score_gemma":0.002052617,"domain_scores_codex":[0.9992654,0.0004056089,0.00006536015,0.0000888725,0.00007476303,0.00009989393],"domain_scores_gemma":[0.9991364,0.0001808933,0.0002452201,0.00006283254,0.00004190206,0.0003327162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8881136,0.02921503,0.002465211,0.001351528,0.002373296,0.0001210815,0.0001378176,0.0006279696,0.0131759,0.0001136959,0.001301632,0.06100332],"study_design_scores_gemma":[0.8095181,0.1831544,0.004323144,0.00006015724,0.0006786477,0.0001026445,0.00002298272,0.000275198,0.0006823537,0.0000555012,0.001111426,0.00001547431],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815307,0.0115663,0.0007698499,0.0004815021,0.0002750679,0.002861153,0.0007121771,0.0001732332,0.001629988],"genre_scores_gemma":[0.9852448,0.006226994,0.001478119,0.001079541,0.0004458854,0.002911839,0.001170332,0.00003574706,0.001406722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003664959,"threshold_uncertainty_score":0.01415825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1231435997574777,"score_gpt":0.4210088676329488,"score_spread":0.2978652678754711,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}