{"id":"W2469090867","doi":"10.1515/hsz-2015-0149","title":"C-reactive protein and inflammation: conformational changes affect function","year":2015,"lang":"en","type":"review","venue":"Biological Chemistry","topic":"Adipokines, Inflammation, and Metabolic Diseases","field":"Medicine","cited_by":286,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Canadian Institutes of Health Research","keywords":"Inflammation; Pentamer; Context (archaeology); C-reactive protein; Cell biology; Chemistry; Mediator; Receptor; Biology; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002452135,0.0003378559,0.0009847103,0.00004171702,0.00005799461,0.00002576302,0.00007264173,0.0005258011,0.0002982006],"category_scores_gemma":[0.0004238469,0.0002140555,0.0001606696,0.0001191441,0.0001432406,0.00006778586,0.00005410745,0.0002432935,0.00005325073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008230817,"about_ca_system_score_gemma":0.0003249354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001503815,"about_ca_topic_score_gemma":2.370775e-7,"domain_scores_codex":[0.9988707,0.00005285581,0.000363327,0.0003062536,0.0002229699,0.000183838],"domain_scores_gemma":[0.9989638,0.00007097574,0.0003333263,0.000198679,0.0001904508,0.0002427435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001366081,0.00006158991,0.00003230034,0.01914092,0.0002707521,0.00001275705,0.00002725951,8.276002e-8,0.0005719573,0.0002688318,0.0007279851,0.978749],"study_design_scores_gemma":[0.0003911556,0.00008735812,0.0001367242,0.002129948,0.0005642827,0.0001153208,0.00002420832,0.000002870154,0.0002387107,0.00007946281,0.995995,0.0002349862],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003719487,0.9875684,0.00001654715,0.0000647737,0.00006723688,0.001134017,0.00009929285,0.0001217975,0.007208392],"genre_scores_gemma":[0.0007315108,0.9898046,0.00008762641,0.00004732089,0.002469108,0.0006979771,0.004220618,0.00002292951,0.001918326],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.995267,"threshold_uncertainty_score":0.8728932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06899143822041495,"score_gpt":0.3202177442538563,"score_spread":0.2512263060334413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}