{"id":"W2469206596","doi":"10.1128/aem.01354-16","title":"Disruption of the Reductive 1,3-Propanediol Pathway Triggers Production of 1,2-Propanediol for Sustained Glycerol Fermentation by Clostridium pasteurianum","year":2016,"lang":"en","type":"article","venue":"Applied and Environmental Microbiology","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of Waterloo","funders":"Networks of Centres of Excellence of Canada; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Government of Canada","keywords":"1,3-Propanediol; Glycerol; Metabolite; Fermentation; Butanol; Chemistry; Biodiesel; Metabolic engineering; Biochemistry; Propanediol; Biodiesel production; Ethanol; Food science; Organic chemistry; Enzyme; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001056531,0.0005391442,0.0002231483,0.0001046399,0.0001389307,0.0003227342,0.0003690207,0.0003252131,0.0006372833],"category_scores_gemma":[0.0001305794,0.0001281405,0.0002427806,0.0001546937,0.0002471692,0.0001609614,0.0004332578,0.0006289998,0.0003148774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004456318,"about_ca_system_score_gemma":0.0003748791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001539168,"about_ca_topic_score_gemma":0.001312342,"domain_scores_codex":[0.9997888,0.00001642997,0.00001515849,0.00004007334,0.00007303499,0.00006647654],"domain_scores_gemma":[0.9998907,0.00001634081,0.00004544759,0.00001292794,0.00001257241,0.0000220566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006608014,0.00002300379,0.0001004651,0.00001497972,0.000001751894,0.00001991253,0.000006527681,0.00006815922,0.999288,0.00001980524,0.00001454753,0.0003767157],"study_design_scores_gemma":[0.000008842313,0.0001426002,0.001826768,0.000003563906,0.00000674422,0.00006388263,0.00001835773,0.0009236886,0.9964629,0.00001816466,0.0005201505,0.000004367667],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963217,0.0002778257,0.002192301,0.00009019093,0.00001916895,0.00002957319,0.0003546723,0.00009161315,0.0006230856],"genre_scores_gemma":[0.995573,0.0001602122,0.002821236,0.0000279278,0.000003603758,0.00002923684,0.0005139532,0.0000307628,0.0008400832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001539168,"threshold_uncertainty_score":0.003233314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002635743543088466,"score_gpt":0.1687971416510527,"score_spread":0.1661613981079642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}