{"id":"W2469213834","doi":"10.1182/blood.v108.11.1609.1609","title":"The Natural History of the Neutrophil Elastase and Coagulation Factor Response to E.coli in a Baboon Model of E.coli/Sepsis Suggests That Elevated Neutrophil Elastase Activity Is Sustained Regardless of Outcome in Clinical Sepsis.","year":2006,"lang":"en","type":"article","venue":"Blood","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Fibrinogen; Elastase; Escherichia coli; Sepsis; Neutrophil elastase; Baboon; Antigen; Protease; Internal medicine; Immunology; Medicine; Pharmacology; Microbiology; Biology; Chemistry; Biochemistry; Enzyme; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002349774,0.0004337436,0.0002494515,0.0003479428,0.0002359866,0.000292015,0.0001160762,0.0004393899,0.001676486],"category_scores_gemma":[0.0002128839,0.0002359245,0.0002072075,0.0001106046,0.0004129774,0.0002827421,0.000206479,0.001366896,0.0003036582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002432702,"about_ca_system_score_gemma":0.000217407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004602238,"about_ca_topic_score_gemma":0.0008704097,"domain_scores_codex":[0.9998466,0.00003262375,0.000009853065,0.00004104089,0.00002321756,0.0000465521],"domain_scores_gemma":[0.9996829,0.00003205653,0.00007735698,0.00002829389,0.00002375734,0.0001556713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002372537,0.0008799851,0.007365563,0.00008513818,0.00002354558,0.0007504249,0.00009207273,0.000139182,0.9847406,0.0002163391,0.0001434424,0.003191116],"study_design_scores_gemma":[0.0002949637,0.05091546,0.2529751,0.00009631497,0.0001498417,0.008619375,0.0005733774,0.003586669,0.6782535,0.0006182418,0.003858245,0.00005882739],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976405,0.0005962488,0.0008123528,0.00008305982,0.00002013897,0.00004133206,0.0001881816,0.00002572271,0.0005925014],"genre_scores_gemma":[0.9954154,0.0006133257,0.001002973,0.0001076965,0.00001116679,0.000132809,0.0004309322,0.000009080051,0.002276577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001676486,"threshold_uncertainty_score":0.005608439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04351103143592146,"score_gpt":0.3047625697028014,"score_spread":0.26125153826688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}