{"id":"W2469730850","doi":"10.1007/0-306-46881-6_244","title":"H-Tyr-Tic-Phe-OH related δ opioid agonists and antagonists have similar receptor-bound conformations but different pharmacophores","year":2006,"lang":"en","type":"book-chapter","venue":"Kluwer Academic Publishers eBooks","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Clinical Research Institute","funders":"","keywords":"Pharmacophore; Stereochemistry; Chemistry; Opioid receptor; Pharmacology; Opioid; Receptor; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006736876,0.0002434962,0.0002529947,0.0000882148,0.0001319782,0.0003875498,0.0003840507,0.0002979715,0.006347286],"category_scores_gemma":[0.00005041832,0.0001544812,0.0001683186,0.0001405557,0.0001885156,0.0004916251,0.0002117141,0.0009167123,0.004077325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001700311,"about_ca_system_score_gemma":0.0001038547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002269605,"about_ca_topic_score_gemma":0.0003285119,"domain_scores_codex":[0.9999677,0.000003404728,0.000001528326,0.000007123415,0.00001279669,0.000007499255],"domain_scores_gemma":[0.999977,0.00001021636,0.000002941181,0.000002719248,0.0000023606,0.000004669279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000241402,0.00008872995,0.0001017556,0.0004131258,0.0000165022,0.000479494,0.0001150992,0.0008904987,0.7605619,0.01824969,0.006323129,0.2125186],"study_design_scores_gemma":[0.00006869614,0.0007877678,0.002259226,0.00007991275,0.00004274199,0.003455183,0.0001635649,0.00207583,0.4312304,0.00672945,0.5530414,0.00006592755],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.2954063,0.1158321,0.05960107,0.002416103,0.001721899,0.0001631296,0.001113069,0.00102638,0.52272],"genre_scores_gemma":[0.4164474,0.06450996,0.02770575,0.002387185,0.0002040578,0.0001552736,0.0008858775,0.0001725935,0.4875319],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.006347286,"threshold_uncertainty_score":0.02123386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02783187732001841,"score_gpt":0.2577362785284742,"score_spread":0.2299044012084558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}