{"id":"W2469818057","doi":"10.1186/s40478-016-0340-5","title":"From animal models to human disease: a genetic approach for personalized medicine in ALS","year":2016,"lang":"en","type":"review","venue":"Acta Neuropathologica Communications","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":150,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital de l'Enfant-Jésus; Université Laval; Institut Universitaire en Santé Mentale de Québec","funders":"Institute of Aging; Canadian Institutes of Health Research; Consortium canadien en neurodégénérescence associée au vieillissement","keywords":"Amyotrophic lateral sclerosis; Optineurin; C9orf72; Disease; SOD1; Personalized medicine; Medicine; Genetic testing; Bioinformatics; Human genetics; Gene; Genetics; Computational biology; Biology; Frontotemporal dementia; Dementia; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003287537,0.0007366742,0.001088358,0.001497643,0.0003623558,0.001948196,0.001003078,0.002502598,0.001552848],"category_scores_gemma":[0.001661008,0.0003756428,0.0007681638,0.0007451792,0.001863656,0.002702709,0.001201577,0.004457613,0.0008951788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001511157,"about_ca_system_score_gemma":0.0008899579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005841882,"about_ca_topic_score_gemma":0.0009761894,"domain_scores_codex":[0.9988289,0.0005136861,0.0001028826,0.0001550734,0.0003242402,0.00007514775],"domain_scores_gemma":[0.9991528,0.000432629,0.00006243742,0.00009224784,0.0002002537,0.00005969149],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000282307,0.0004551702,0.001261139,0.008496897,0.000232158,0.001397092,0.0008477811,0.002590512,0.1846824,0.1996642,0.05624656,0.5438437],"study_design_scores_gemma":[0.00003198598,0.0008763996,0.001097195,0.001725755,0.0002060711,0.002964546,0.0002328169,0.001576215,0.0397056,0.0360513,0.9154325,0.00009967751],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.008454667,0.8517649,0.0944541,0.02360949,0.005713921,0.0001743396,0.0003421131,0.0006087782,0.01487765],"genre_scores_gemma":[0.04768841,0.8473942,0.07922672,0.01150692,0.002246619,0.0002815145,0.0004912434,0.0001969532,0.01096745],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003287537,"threshold_uncertainty_score":0.01738638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3380808511836139,"score_gpt":0.4458445550403553,"score_spread":0.1077637038567414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}