{"id":"W2469889112","doi":"10.1016/j.jep.2016.07.037","title":"Comparative proteomic and metabolomic analysis reveal the antiosteoporotic molecular mechanism of icariin from Epimedium brevicornu maxim","year":2016,"lang":"en","type":"article","venue":"Journal of Ethnopharmacology","topic":"Medicinal Plant Pharmacodynamics Research","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Natural Science Foundation of China","keywords":"Icariin; Epimedium; Traditional medicine; Mechanism (biology); Pharmacognosy; Chemistry; Biology; Medicine; Biochemistry; Biological activity; Philosophy; Pathology; Medicinal herbs; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.003968857,0.0003715755,0.001460298,0.0007213679,0.0001666675,0.00001438878,0.000966553,0.0003875482,0.002023051],"category_scores_gemma":[0.0002800707,0.0002149086,0.0003683665,0.0007843721,0.00102374,0.0002001647,0.0002701611,0.001686119,0.00003547474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000121856,"about_ca_system_score_gemma":0.0003393992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005112811,"about_ca_topic_score_gemma":0.00001120458,"domain_scores_codex":[0.99397,0.003000749,0.001413252,0.0004062135,0.0005964947,0.0006132629],"domain_scores_gemma":[0.9941395,0.003073853,0.001429647,0.0002756279,0.000617,0.0004643734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002414017,0.0002365425,0.003831969,0.0000553247,0.006391064,0.0003030786,0.0006280424,0.0002138335,0.9810488,0.0005181395,0.001463157,0.002896014],"study_design_scores_gemma":[0.007075514,0.0008638768,0.01187742,0.0000715995,0.00929927,0.0001512747,0.0002567946,0.004666245,0.9608738,0.002686767,0.001835732,0.0003416438],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876245,0.002455434,0.001759773,0.005481157,0.001397617,0.0008142778,0.0002191461,0.00001522919,0.0002329091],"genre_scores_gemma":[0.9955829,0.002152303,0.0005629533,0.00110723,0.0003010645,0.00003165854,0.000009030636,0.00002571136,0.0002270835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02017495,"threshold_uncertainty_score":0.9988892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1097246814257432,"score_gpt":0.4572562313620983,"score_spread":0.3475315499363552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}