{"id":"W2469928227","doi":"10.1021/acschemneuro.6b00097","title":"Identification of 2-({[1-(4-Fluorophenyl)-5-(2-methoxyphenyl)-1<i>H</i>-pyrazol-3-yl]carbonyl}amino)tricyclo[3.3.1.13,7]decane-2-carboxylic Acid (NTRC-844) as a Selective Antagonist for the Rat Neurotensin Receptor Type 2","year":2016,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"National Institute on Drug Abuse; National Institute of Mental Health; Canadian Institutes of Health Research","keywords":"Agonist; Antagonist; In vivo; Neurotensin; Chemistry; Pharmacology; Receptor; Carboxylic acid; Stereochemistry; Analgesic; Medicine; Biochemistry; Neuropeptide; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001474855,0.0003417543,0.0003868916,0.0002253433,0.000182952,0.0001630216,0.00027009,0.0003293288,0.002503524],"category_scores_gemma":[0.0001566444,0.0001266673,0.0001746049,0.000138246,0.0001610589,0.0001989613,0.0001613412,0.0003242952,0.0007525886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002653542,"about_ca_system_score_gemma":0.0005194534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006566187,"about_ca_topic_score_gemma":0.001693379,"domain_scores_codex":[0.9999084,0.00001685621,0.000006533155,0.00002011948,0.00001983752,0.00002828441],"domain_scores_gemma":[0.9999286,0.00000870289,0.00001783309,0.000005175717,0.00001757279,0.00002209567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002134689,0.00004651417,0.0001283242,0.0000698986,0.000004926338,0.0001456258,0.00001229462,0.0001159705,0.9967346,0.0001044636,0.00005517703,0.002368729],"study_design_scores_gemma":[0.0001872517,0.003526242,0.004468041,0.00001624952,0.00004186454,0.001140666,0.0000228316,0.001162171,0.9831215,0.00006666598,0.00622811,0.00001844233],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842419,0.003509559,0.005865674,0.0002191204,0.00006863243,0.0002278274,0.0006518281,0.00009031771,0.005125091],"genre_scores_gemma":[0.9814475,0.002174773,0.008143836,0.0001344156,0.00003773366,0.0001503509,0.0009185866,0.00001681953,0.006976036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002503524,"threshold_uncertainty_score":0.008375108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02740370118245994,"score_gpt":0.2796049255399405,"score_spread":0.2522012243574805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}