{"id":"W2469928227","doi":"10.1021/acschemneuro.6b00097","title":"Identification of 2-({[1-(4-Fluorophenyl)-5-(2-methoxyphenyl)-1<i>H</i>-pyrazol-3-yl]carbonyl}amino)tricyclo[3.3.1.13,7]decane-2-carboxylic Acid (NTRC-844) as a Selective Antagonist for the Rat Neurotensin Receptor Type 2","year":2016,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"National Institute on Drug Abuse; National Institute of Mental Health; Canadian Institutes of Health Research","keywords":"Agonist; Antagonist; In vivo; Neurotensin; Chemistry; Pharmacology; Receptor; Carboxylic acid; Stereochemistry; Analgesic; Medicine; Biochemistry; Neuropeptide; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004332151,0.0005356296,0.0005888949,0.0001248082,0.0005332788,0.0001594138,0.001956626,0.0001682723,0.00003151839],"category_scores_gemma":[0.009093459,0.0003420023,0.0002640609,0.001848464,0.001952986,0.0005044963,0.0005157815,0.0004299752,0.0001078057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000814453,"about_ca_system_score_gemma":0.0002266436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002155713,"about_ca_topic_score_gemma":0.000001256873,"domain_scores_codex":[0.9950794,0.0002692839,0.0009450478,0.001876735,0.0007900605,0.001039465],"domain_scores_gemma":[0.9952304,0.002337552,0.0006671618,0.001112816,0.000375258,0.0002767864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005028918,0.0001697132,0.00004982398,0.00002347194,0.000003963229,0.00001076401,0.00005546149,0.000007846837,0.9925497,0.0008998222,0.001523307,0.004203274],"study_design_scores_gemma":[0.0007293164,0.0005703478,0.0006585844,0.00002852477,0.00004252471,0.0000765508,0.00001511468,0.0003165828,0.9860563,0.001500112,0.009587689,0.0004183659],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936717,0.00005618436,0.000385854,0.002244725,0.001787954,0.001217605,0.0001022416,0.0001833893,0.000350335],"genre_scores_gemma":[0.9942487,0.0004184356,0.0001170582,0.003889485,0.0003079563,0.0001112019,0.000002907859,0.00008884455,0.000815441],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008660243,"threshold_uncertainty_score":0.9999032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02740370118245994,"score_gpt":0.2796049255399405,"score_spread":0.2522012243574805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}