{"id":"W2469938764","doi":"10.1038/nm.4126","title":"Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice","year":2016,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":335,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Arthritis and Musculoskeletal and Skin Diseases","keywords":"Cell biology; Fibronectin; Stem cell; Biology; Extracellular matrix; Focal adhesion; Skeletal muscle; Integrin; Phenotype; Immunology; Cell; Signal transduction; Genetics; Anatomy; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003086148,0.0006476272,0.000345788,0.001026478,0.000243417,0.0005629055,0.0004525852,0.001035327,0.002361441],"category_scores_gemma":[0.0002090437,0.0004549636,0.0003752878,0.0002202854,0.0008389301,0.0004020061,0.0003738252,0.001145209,0.000486171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006395025,"about_ca_system_score_gemma":0.0003462434,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00176122,"about_ca_topic_score_gemma":0.003637078,"domain_scores_codex":[0.9995692,0.00004887984,0.00004575448,0.00009615677,0.0001390928,0.0001008733],"domain_scores_gemma":[0.999312,0.00007224766,0.000272314,0.00003926434,0.00003337464,0.0002707199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001805781,0.00002070404,0.0001391381,0.00001506063,0.000006195735,0.00006725679,0.000009908425,0.00009028184,0.9988832,0.00008436253,0.0000252193,0.000478257],"study_design_scores_gemma":[0.00006980247,0.0005959595,0.01275274,0.00001626975,0.00007068868,0.0006260553,0.00009323568,0.00200886,0.9813882,0.0002634531,0.002094069,0.00002062432],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945133,0.001003496,0.002259523,0.000195504,0.00004732768,0.00001362408,0.0006815157,0.0001531678,0.001132643],"genre_scores_gemma":[0.9891781,0.0005526697,0.002078497,0.0001528272,0.00002639135,0.00003029788,0.0005553658,0.0001372277,0.007288591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002361441,"threshold_uncertainty_score":0.007899821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00676808750864249,"score_gpt":0.2308743181416997,"score_spread":0.2241062306330572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}