{"id":"W2470063159","doi":"10.1111/jnc.13719","title":"Cerebrospinal fluid total tau concentration predicts clinical phenotype in Huntington's disease","year":2016,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; Shire; Knut och Alice Wallenbergs Stiftelse; Wolfson Foundation; University College London Hospitals NHS Foundation Trust; Rosetrees Trust; Ionis Pharmaceuticals; Wellcome Trust; National Institute for Health and Care Research; Teva Pharmaceutical Industries; University College London; CHDI Foundation; European Research Council; Huntington Society of Canada; Wellcome; GlaxoSmithKline; Vetenskapsrådet; Pfizer","keywords":"Huntington's disease; Cerebrospinal fluid; Phenotype; Clinical phenotype; Disease; Pathology; Neuroscience; Medicine; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001928726,0.0001846384,0.0002565361,0.00004186306,0.00005550262,0.00004858109,0.0003586944,0.00006056657,0.0001128819],"category_scores_gemma":[0.00524875,0.0001372469,0.000182989,0.0001584134,0.0002030748,0.0002406677,0.0000791733,0.0002577014,0.0000181568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004515352,"about_ca_system_score_gemma":0.0003555269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":3.135818e-7,"about_ca_topic_score_gemma":1.160331e-7,"domain_scores_codex":[0.9977325,0.0002254449,0.0008121144,0.0003934528,0.0005328189,0.0003037037],"domain_scores_gemma":[0.9983096,0.0003562697,0.0004905449,0.0002644987,0.0001516284,0.0004274953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002969011,0.0002683524,0.04068522,0.00002214865,0.000003000292,0.0001436107,0.00001163855,0.00005422119,0.9567476,0.00002217983,0.0008019135,0.0009432297],"study_design_scores_gemma":[0.001302059,0.0001573955,0.3863836,0.00009434568,0.00002082305,0.00003927001,0.000005676236,0.00005652216,0.6115404,0.0001030179,0.0001752833,0.0001216828],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977745,0.00005252476,0.0001396079,0.0009765282,0.0006468817,0.00009785763,0.00002519502,0.0000172406,0.0002696357],"genre_scores_gemma":[0.9983698,0.0001124407,0.00005533443,0.0005691418,0.0006674424,0.000002966543,7.439222e-7,0.00002195286,0.0002001375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3456983,"threshold_uncertainty_score":0.6283623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02862101238116843,"score_gpt":0.2998198635921689,"score_spread":0.2711988512110005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}