{"id":"W2470063159","doi":"10.1111/jnc.13719","title":"Cerebrospinal fluid total tau concentration predicts clinical phenotype in Huntington's disease","year":2016,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; Shire; Knut och Alice Wallenbergs Stiftelse; Wolfson Foundation; University College London Hospitals NHS Foundation Trust; Rosetrees Trust; Ionis Pharmaceuticals; Wellcome Trust; National Institute for Health and Care Research; Teva Pharmaceutical Industries; University College London; CHDI Foundation; European Research Council; Huntington Society of Canada; Wellcome; GlaxoSmithKline; Vetenskapsrådet; Pfizer","keywords":"Huntington's disease; Cerebrospinal fluid; Phenotype; Clinical phenotype; Disease; Pathology; Neuroscience; Medicine; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007320581,0.0005884596,0.0004804611,0.0007283072,0.0003685466,0.000595895,0.0002435874,0.0006788258,0.001233627],"category_scores_gemma":[0.002555091,0.0002594183,0.0002194521,0.0004166581,0.0002970299,0.0004294417,0.0003883809,0.0004688712,0.0003718362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000142293,"about_ca_system_score_gemma":0.0001371932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001069535,"about_ca_topic_score_gemma":0.001107006,"domain_scores_codex":[0.9997641,0.00007182847,0.0000385462,0.00005561039,0.00004436637,0.00002556747],"domain_scores_gemma":[0.9986317,0.0004365651,0.0004045885,0.00005883801,0.0001701716,0.0002982162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000687374,0.00007425568,0.9954181,0.00001443762,0.00003798915,0.0001991642,0.00007843345,0.00005684657,0.00139306,0.000007841762,0.00008632157,0.001946371],"study_design_scores_gemma":[0.00001149727,0.0002507742,0.9988086,0.000007287837,0.00001851663,0.000444256,0.00007672838,0.0001762819,0.0001176936,0.00002339227,0.00006163665,0.000003295551],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992424,0.0003315468,0.0000617033,0.00001680038,0.000007214228,0.000007771245,0.00009618668,0.00000629741,0.0002301443],"genre_scores_gemma":[0.9994838,0.00009965977,0.00009001956,0.00001307155,0.000008938834,0.00000754684,0.0001650572,0.000001840832,0.0001300099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001233627,"threshold_uncertainty_score":0.004126906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02862101238116843,"score_gpt":0.2998198635921689,"score_spread":0.2711988512110005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}