{"id":"W2470077082","doi":"10.1038/cmi.2016.23","title":"Novel exosome-targeted T-cell-based vaccine counteracts T-cell anergy and converts CTL exhaustion in chronic infection via CD40L signaling through the mTORC1 pathway","year":2016,"lang":"en","type":"article","venue":"Cellular and Molecular Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"Canadian Institutes of Health Research; University of Saskatchewan","keywords":"CTL*; Cytotoxic T cell; Biology; Immunology; CD8; T cell; Granzyme B; FOXP3; Immune system; Virology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002614566,0.0003663538,0.0003791813,0.000215785,0.0002717196,0.00003321693,0.0001428837,0.0004768271,0.0004544543],"category_scores_gemma":[0.00004609616,0.0002606018,0.0001084567,0.0001845829,0.0002341645,0.0002457599,0.00009900422,0.000459085,0.0001164237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002049265,"about_ca_system_score_gemma":0.0001116034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006768315,"about_ca_topic_score_gemma":0.00005110799,"domain_scores_codex":[0.9979982,0.0003730445,0.0005020623,0.0005558992,0.00005695902,0.0005138515],"domain_scores_gemma":[0.9990113,0.0001878371,0.0002625961,0.0003972936,0.0001145295,0.00002640581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003964696,0.0001819288,0.0003069131,0.0000408746,0.00008912264,0.00001844154,0.0001895277,0.0001090775,0.9963708,0.0002254937,0.0001628225,0.001908561],"study_design_scores_gemma":[0.005608716,0.0005813376,0.0009045691,0.00008645197,0.0000589897,0.000134764,0.00008107646,0.0001433263,0.9412218,0.00007228296,0.05077862,0.0003280999],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8892353,0.02166681,0.08524721,0.000462523,0.002295246,0.0004777991,0.000004971741,0.00009309161,0.0005170836],"genre_scores_gemma":[0.9967777,0.0009059218,0.00002803348,0.0005402651,0.00003915842,0.00005874971,0.0001742158,0.00004290321,0.001433053],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1075424,"threshold_uncertainty_score":0.9999846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005880185839351313,"score_gpt":0.1949984413620661,"score_spread":0.1891182555227148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}