{"id":"W2470077082","doi":"10.1038/cmi.2016.23","title":"Novel exosome-targeted T-cell-based vaccine counteracts T-cell anergy and converts CTL exhaustion in chronic infection via CD40L signaling through the mTORC1 pathway","year":2016,"lang":"en","type":"article","venue":"Cellular and Molecular Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"Canadian Institutes of Health Research; University of Saskatchewan","keywords":"CTL*; Cytotoxic T cell; Biology; Immunology; CD8; T cell; Granzyme B; FOXP3; Immune system; Virology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001068255,0.0002986743,0.0003088853,0.0001700265,0.0001110249,0.0003033136,0.0002048418,0.0002857249,0.001211585],"category_scores_gemma":[0.0000582211,0.00008988225,0.0002221091,0.00007575146,0.0001911409,0.000323633,0.0002002398,0.0006180606,0.0002761574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001861665,"about_ca_system_score_gemma":0.0002007517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001025026,"about_ca_topic_score_gemma":0.0001558395,"domain_scores_codex":[0.9999248,0.00001038615,0.00000585411,0.00001429383,0.00001536057,0.00002936895],"domain_scores_gemma":[0.9999758,0.000002727894,0.00000722912,0.000002607347,0.000003566034,0.000007959384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006256374,0.0002161037,0.0001929368,0.0001075023,0.00001487316,0.00007827459,0.00001037259,0.000257601,0.9893177,0.0003231416,0.0002737437,0.008582144],"study_design_scores_gemma":[0.0002532098,0.001894785,0.002105249,0.00001475932,0.00008096653,0.0005079747,0.00002917782,0.003056473,0.985884,0.0002249145,0.005937407,0.00001112839],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903626,0.003297038,0.004084094,0.0002460663,0.0001183544,0.00006435321,0.0001943831,0.0001436725,0.001489494],"genre_scores_gemma":[0.9963881,0.0007673034,0.001408097,0.00007487879,0.00001876311,0.00004394943,0.000206845,0.00001183613,0.001080341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001211585,"threshold_uncertainty_score":0.004053175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005880185839351313,"score_gpt":0.1949984413620661,"score_spread":0.1891182555227148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}