{"id":"W2470196071","doi":"10.1016/j.cbpa.2016.06.015","title":"Rethinking translational nanomedicine: insights from the ‘bottom-up’ design of the Porphysome for guiding the clinical development of imageable nanomaterials","year":2016,"lang":"en","type":"review","venue":"Current Opinion in Chemical Biology","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Terry Fox Foundation; Prostate Cancer Canada; Natural Sciences and Engineering Research Council of Canada; Princess Margaret Cancer Foundation; Canadian Foundation for Climate and Atmospheric Sciences; Institute for Journalism and Natural Resources; Ovarian Cancer Research Fund; Ontario Institute for Cancer Research; Conquer Cancer Foundation","keywords":"Nanomedicine; Nanotechnology; Exploit; Computer science; Materials science; Nanoparticle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001230806,0.0006803098,0.0009076612,0.0005029097,0.0002831352,0.00154797,0.001180124,0.001695064,0.001548065],"category_scores_gemma":[0.0006161128,0.0003469915,0.0004727258,0.0004424997,0.001709139,0.003230775,0.001444747,0.003445406,0.0009484558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009694545,"about_ca_system_score_gemma":0.0008284599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000454434,"about_ca_topic_score_gemma":0.001103813,"domain_scores_codex":[0.9996778,0.00007049754,0.00001669597,0.00006287851,0.0001172988,0.00005488841],"domain_scores_gemma":[0.9997581,0.0001168648,0.00003363851,0.00001764785,0.00005038272,0.00002336231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001556774,0.0001808549,0.0002331505,0.009122403,0.00008068116,0.000591417,0.000367232,0.001840246,0.2069808,0.08506737,0.01749755,0.6778827],"study_design_scores_gemma":[0.00005075613,0.0004712844,0.0005766349,0.001044143,0.00007314183,0.001461569,0.0001686968,0.002438402,0.09789487,0.02625701,0.8694942,0.00006932449],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005152124,0.9523719,0.02748804,0.007954575,0.001078701,0.00005989235,0.00005692568,0.0001111832,0.00572662],"genre_scores_gemma":[0.05497447,0.9140032,0.02169768,0.00354618,0.0007289542,0.00007081604,0.000083978,0.00005128099,0.004843397],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001695064,"threshold_uncertainty_score":0.007033944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2526384227512053,"score_gpt":0.4111763319737303,"score_spread":0.158537909222525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}