{"id":"W2470303798","doi":"10.2119/molmed.2015.00017","title":"Mouse Model for Protein Tyrosine Phosphatase D (PTPRD) Associations with Restless Leg Syndrome or Willis-Ekbom Disease and Addiction: Reduced Expression Alters Locomotion, Sleep Behaviors and Cocaine-Conditioned Place Preference","year":2015,"lang":"en","type":"article","venue":"Molecular Medicine","topic":"Restless Legs Syndrome Research","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute on Drug Abuse; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Addiction; Phenotype; Biology; Protein tyrosine phosphatase; Gene; Disease; Genetics; Neuroscience; Medicine; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005877693,0.0003792063,0.0006252833,0.0002976134,0.0002326885,0.00005144465,0.000150583,0.0001619323,0.00004417604],"category_scores_gemma":[0.001193778,0.0002732623,0.00004500074,0.0003862139,0.0004080989,0.0003137682,0.00009384623,0.00034131,0.000003086306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002461879,"about_ca_system_score_gemma":0.0005294686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001077059,"about_ca_topic_score_gemma":0.00002033406,"domain_scores_codex":[0.9970563,0.0001538965,0.0004865996,0.0007390775,0.001075304,0.0004888328],"domain_scores_gemma":[0.9970322,0.00009146819,0.0002261356,0.0006248547,0.0006115252,0.001413783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.01869232,0.00262027,0.009159865,0.00229637,0.0009116782,0.004117326,0.003677159,0.005817701,0.9355252,0.001187734,0.01443396,0.001560439],"study_design_scores_gemma":[0.1638631,0.03058515,0.1358164,0.02120032,0.007781711,0.003998706,0.002887051,0.3768371,0.2485782,0.002365055,0.001357513,0.004729698],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9667049,0.001541678,0.02211911,0.005320247,0.0000475656,0.003646791,0.0004666297,0.0001272412,0.00002581725],"genre_scores_gemma":[0.9913948,0.00008282371,0.003210892,0.0002374693,0.0000612255,0.001158133,0.001700298,0.00009248374,0.002061924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.686947,"threshold_uncertainty_score":0.999972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0543771040834541,"score_gpt":0.3145725541751821,"score_spread":0.260195450091728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}