{"id":"W2470408178","doi":"10.1128/aac.00365-16","title":"A Multinational, Preregistered Cohort Study of β-Lactam/β-Lactamase Inhibitor Combinations for Treatment of Bloodstream Infections Due to Extended-Spectrum-β-Lactamase-Producing Enterobacteriaceae","year":2016,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"European Regional Development Fund; NIH Clinical Center; National Institutes of Health; Ministerio de Economía y Competitividad; Instituto de Salud Carlos III; U.S. Department of Veterans Affairs; European Society of Clinical Microbiology and Infectious Diseases; Geriatric Research Education and Clinical Center; European Federation of Pharmaceutical Industries and Associations; National Institute of Allergy and Infectious Diseases; European Commission","keywords":"Internal medicine; Medicine; Odds ratio; Retrospective cohort study; Carbapenem; Beta-Lactamase Inhibitors; Confidence interval; Cohort; Propensity score matching; Mortality rate; Bacteremia; Cohort study; Microbiology; Antibiotics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001050514,0.0002393758,0.0003774684,0.00009535412,0.0001040176,0.00002552231,0.0001189475,0.00009558122,0.00003146346],"category_scores_gemma":[0.00003531968,0.0001852489,0.000115253,0.00009130307,0.00009864184,0.00001501974,0.00004352567,0.00001691942,0.00000103448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004139982,"about_ca_system_score_gemma":0.0000467263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009935608,"about_ca_topic_score_gemma":0.000149419,"domain_scores_codex":[0.9986825,0.00005193559,0.0004318813,0.0005110989,0.0001029382,0.0002196664],"domain_scores_gemma":[0.9990462,0.00003420779,0.0002711395,0.0004163234,0.0001550022,0.00007710657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004128623,0.004702063,0.5464471,0.00004011071,0.0003457362,0.000001132315,0.0003553626,0.000001873509,0.4449576,0.00001874272,0.001075434,0.001641951],"study_design_scores_gemma":[0.006673584,0.003093096,0.7033389,0.00008676097,0.00007953849,0.00001059556,0.00009620057,0.000003425259,0.2830207,0.00001381939,0.003362197,0.0002211614],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965128,0.000009153955,0.0009441634,0.0004895445,0.0001582685,0.00160739,0.000233794,0.00001319105,0.00003169513],"genre_scores_gemma":[0.9982058,0.000208919,0.0005827291,0.0001210223,0.0001100245,0.00006064,0.00008588791,0.00003810641,0.0005868317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1619369,"threshold_uncertainty_score":0.7554232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0116379885525628,"score_gpt":0.2692196275064886,"score_spread":0.2575816389539258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}