{"id":"W2470644820","doi":"10.1038/ncomms12156","title":"ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":117,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital du Sacré-Cœur de Montréal; McGill University","funders":"Congressionally Directed Medical Research Programs; Terry Fox Research Institute; Canadian Institutes of Health Research; Fondation du cancer du sein du Québec; McGill University; U.S. Department of Defense","keywords":"Lapatinib; Cancer research; Breast cancer; Cancer; Pharmacology; PI3K/AKT/mTOR pathway; Cancer cell; Receptor tyrosine kinase; Medicine; Biology; Receptor; Internal medicine; Trastuzumab; Signal transduction; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001981394,0.0001364361,0.0001645422,0.00007532333,0.0001364768,0.00001806425,0.0007700144,0.0002388569,0.00006418702],"category_scores_gemma":[0.0001909942,0.0001062837,0.00006844775,0.0002543782,0.0001420208,0.00001388422,0.0001918908,0.0002642328,0.00001041947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002540717,"about_ca_system_score_gemma":0.000153307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004094344,"about_ca_topic_score_gemma":0.01723879,"domain_scores_codex":[0.9990022,0.0001540189,0.0002331435,0.0002504793,0.000128631,0.0002315003],"domain_scores_gemma":[0.9982616,0.00009101636,0.0001084566,0.001279713,0.0001874897,0.00007175114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001146724,0.000561422,0.1661866,0.00003252207,0.0003667686,0.000001361353,0.0009482889,0.00002568686,0.3133884,0.06646883,0.06140994,0.3904955],"study_design_scores_gemma":[0.0004648206,0.000004316234,0.1506892,0.00006180858,0.00002652852,8.470748e-7,0.0000461731,0.000008096675,0.006115216,0.0004140697,0.841988,0.0001809145],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1411266,0.8506072,0.0000785423,0.005265534,0.0002745903,0.0001963944,0.0003497271,0.00002793356,0.002073524],"genre_scores_gemma":[0.721664,0.2755215,0.001532975,0.0005199498,0.0001517759,0.0002037924,0.00007185823,0.0000183902,0.0003157881],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.7805781,"threshold_uncertainty_score":0.9619649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01211716495112047,"score_gpt":0.2900438727147905,"score_spread":0.2779267077636701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}