{"id":"W2471289324","doi":"10.1113/jp272419","title":"Pivotal role of α2 Na<sup>+</sup>pumps and their high affinity ouabain binding site in cardiovascular health and disease","year":2016,"lang":"en","type":"review","venue":"The Journal of Physiology","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health; National Institute of Arthritis and Musculoskeletal and Skin Diseases; American Heart Association","keywords":"Ouabain; Homeostasis; Endocrinology; Internal medicine; Chemistry; Angiotensin II; Endogeny; Basal (medicine); Blood pressure; Biology; Medicine; Sodium","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004839088,0.0007126066,0.0009118176,0.00108285,0.0001946843,0.0009939313,0.0007016025,0.0009409856,0.002976631],"category_scores_gemma":[0.0003546346,0.0001898606,0.0002117496,0.001243469,0.0006101473,0.001185388,0.0005904478,0.001538487,0.002567221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005620294,"about_ca_system_score_gemma":0.0007669937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006261109,"about_ca_topic_score_gemma":0.001033399,"domain_scores_codex":[0.9999048,0.00001212742,0.0000140025,0.00001900552,0.00003796574,0.00001211667],"domain_scores_gemma":[0.9997917,0.00005996813,0.00003465777,0.000006209987,0.00007289158,0.00003448837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001216633,0.0000463267,0.0001632256,0.00885011,0.00004803351,0.0002245534,0.00005147183,0.0003425068,0.005183883,0.006256915,0.04223787,0.9364734],"study_design_scores_gemma":[0.0000155377,0.00006282934,0.0009949346,0.001199562,0.00003886639,0.0008458161,0.00004791342,0.0001028491,0.0006502218,0.002506146,0.9935215,0.00001376299],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001549759,0.9974159,0.0001961373,0.0005275166,0.0003013633,0.000002827058,0.00002251353,0.00001147687,0.001367222],"genre_scores_gemma":[0.001300092,0.9964157,0.0002589447,0.0002178805,0.0002908454,0.000005906678,0.00003835184,0.000002789495,0.001469406],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002976631,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01202291035719529,"score_gpt":0.2450817059139635,"score_spread":0.2330587955567682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}