{"id":"W2471290523","doi":"10.4103/1673-5374.184448","title":"The intricacies of neurotrophic factor therapy for retinal ganglion cell rescue in glaucoma: a case for gene therapy","year":2016,"lang":"en","type":"review","venue":"Neural Regeneration Research","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Neurotrophic factors; Neuroscience; Retinal ganglion cell; Neurotrophin; Genetic enhancement; Regeneration (biology); Medicine; Glaucoma; Retina; Bioinformatics; Biology; Gene; Cell biology; Internal medicine; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009161059,0.0002778625,0.0004433963,0.0002197801,0.0003149442,0.00007990608,0.0003961423,0.0002951224,0.000006180793],"category_scores_gemma":[0.0004089385,0.0001575327,0.0003205938,0.0002992283,0.000156185,0.000006849305,0.00007977538,0.0002104704,0.000001752014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003754114,"about_ca_system_score_gemma":0.0004195422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001562645,"about_ca_topic_score_gemma":0.00004586887,"domain_scores_codex":[0.9975088,0.000616724,0.0005681154,0.0005193906,0.0003207146,0.0004662186],"domain_scores_gemma":[0.998418,0.0004121147,0.0001825228,0.0004325478,0.0004905352,0.00006423913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001084607,0.00008929333,0.00002384947,0.0008808679,0.00004212335,0.00002106391,0.00003577737,0.000001961015,0.05111725,0.00008837068,0.003059577,0.9435552],"study_design_scores_gemma":[0.001301799,0.001363528,0.00001293552,0.0001812138,0.000007309658,0.00005403438,0.00001828325,0.00005762757,0.05857732,0.00006777797,0.9381232,0.0002349743],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.09014306,0.9057649,0.000168531,0.0003646517,0.000165826,0.003264193,0.00009695176,0.000005321489,0.00002659744],"genre_scores_gemma":[0.00594394,0.9905056,0.0001628447,0.00002156484,0.0003962756,0.001462784,0.0002552716,0.00005611961,0.00119556],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9433203,"threshold_uncertainty_score":0.6423998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1026896057333891,"score_gpt":0.3993393609275387,"score_spread":0.2966497551941497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}