{"id":"W2471425782","doi":"10.1038/bjc.2016.188","title":"Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer","year":2016,"lang":"en","type":"review","venue":"British Journal of Cancer","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"FP7 Health; National Center for Chronic Disease Prevention and Health Promotion; Kuopion Yliopistollinen Sairaala; National Cancer Institute; Academy of Finland; National Institute on Alcohol Abuse and Alcoholism; Medical Research Council; National Institutes of Health; Goddard Space Flight Center; Centers for Disease Control and Prevention; NordForsk; China Scholarship Council; Jane ja Aatos Erkon Säätiö; Opetus- ja Kulttuuriministeriö; Wellcome Trust; University of Southern California; Cancer Research UK; Netherlands eScience Center; European Commission; Cancer Research Wales; California Department of Public Health; McKnight Foundation; National Institute for Social Care and Health Research; Tenovus","keywords":"Medicine; Body mass index; Odds ratio; Confounding; Internal medicine; Obesity; Waist–hip ratio; Colorectal cancer; Overweight; Waist; Oncology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1073871,0.00168377,0.00370794,0.002026962,0.0009482427,0.001868072,0.00172263,0.002186951,0.004776036],"category_scores_gemma":[0.2041073,0.001012787,0.003488823,0.002319515,0.003295772,0.001679034,0.001312162,0.002274508,0.0006058724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001157365,"about_ca_system_score_gemma":0.001993205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002360114,"about_ca_topic_score_gemma":0.001737495,"domain_scores_codex":[0.843585,0.1250898,0.005564547,0.01418069,0.009668521,0.0019114],"domain_scores_gemma":[0.8317405,0.1275869,0.01556637,0.02126834,0.00316351,0.0006744236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02480297,0.0006527224,0.6520888,0.005012374,0.06173088,0.006955416,0.002999,0.01670962,0.008694064,0.0762983,0.0134511,0.1306048],"study_design_scores_gemma":[0.01487318,0.009263773,0.4372328,0.002320568,0.03855023,0.01612281,0.0008503151,0.1516901,0.007055632,0.2840193,0.03738564,0.0006357171],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"methods","genre_gemma":"review","genre_scores_codex":[0.3218957,0.01095218,0.6417394,0.005824017,0.001564513,0.00524385,0.002229629,0.001491059,0.009059681],"genre_scores_gemma":[0.9177172,0.001294528,0.07311404,0.001715803,0.0003458085,0.003450146,0.0007628572,0.000167146,0.001432512],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.1073871,"threshold_uncertainty_score":0.5679243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01488860212801826,"score_gpt":0.3190005981402095,"score_spread":0.3041119960121912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}