{"id":"W2471503382","doi":"10.1182/blood.v126.23.469.469","title":"Ibrutinib Vs Temsirolimus: Results from a Phase 3, International, Randomized, Open-Label, Multicenter Study in Patients with Previously Treated Mantle Cell Lymphoma (MCL)","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Ibrutinib; Temsirolimus; Mantle cell lymphoma; Medicine; Internal medicine; Clinical endpoint; Phases of clinical research; International Prognostic Index; Oncology; Lymphoma; Febrile neutropenia; Neutropenia; Randomized controlled trial; Gastroenterology; Surgery; Rituximab; Clinical trial; Chemotherapy; Leukemia; Chronic lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001055547,0.0003360466,0.0009528137,0.0002390167,0.00004536873,0.0001395089,0.0006193093,0.0001179844,0.000069751],"category_scores_gemma":[0.0009012517,0.0002381846,0.0000563635,0.0003275187,0.0001245532,0.0002558889,0.000423935,0.0001797206,0.0001633653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002681426,"about_ca_system_score_gemma":0.002109164,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009570891,"about_ca_topic_score_gemma":0.0003175297,"domain_scores_codex":[0.996393,0.0003980839,0.0008611373,0.0007741724,0.001052612,0.0005209466],"domain_scores_gemma":[0.9977283,0.0004245526,0.0002659543,0.0008396898,0.0004027727,0.0003387016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8098717,0.1251865,0.05283891,0.00004303734,0.001014314,0.001089297,0.007142588,0.000004883063,0.00004985737,0.000001258288,0.001374647,0.001383035],"study_design_scores_gemma":[0.987699,0.002814746,0.003512176,0.0002878275,0.0005094786,0.0000100711,0.000610302,0.002653003,0.0009807743,0.000005100949,0.0006616292,0.0002558991],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893251,0.000170555,0.000003305745,0.0001103646,0.0001332085,0.006343853,0.0001888681,0.00006503962,0.003659696],"genre_scores_gemma":[0.9970208,0.00002972381,0.0004369992,0.00015016,0.00009811506,0.0003109722,0.00070709,0.00006724885,0.001178875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1778273,"threshold_uncertainty_score":0.9970245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03903562922247449,"score_gpt":0.3292918694018239,"score_spread":0.2902562401793494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}