{"id":"W2471503382","doi":"10.1182/blood.v126.23.469.469","title":"Ibrutinib Vs Temsirolimus: Results from a Phase 3, International, Randomized, Open-Label, Multicenter Study in Patients with Previously Treated Mantle Cell Lymphoma (MCL)","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Ibrutinib; Temsirolimus; Mantle cell lymphoma; Medicine; Internal medicine; Clinical endpoint; Phases of clinical research; International Prognostic Index; Oncology; Lymphoma; Febrile neutropenia; Neutropenia; Randomized controlled trial; Gastroenterology; Surgery; Rituximab; Clinical trial; Chemotherapy; Leukemia; Chronic lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004182206,0.001835979,0.002557121,0.0004380917,0.0005837362,0.001360038,0.001257713,0.001675073,0.004399215],"category_scores_gemma":[0.00169472,0.0007608815,0.002525557,0.0005237747,0.001352911,0.001199318,0.000533113,0.003060034,0.0008735841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001222465,"about_ca_system_score_gemma":0.001567064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009993531,"about_ca_topic_score_gemma":0.002340195,"domain_scores_codex":[0.9986326,0.0007943854,0.00009037823,0.0002188857,0.00007863513,0.0001850274],"domain_scores_gemma":[0.9985049,0.0003134723,0.0003295359,0.00009504511,0.00007898445,0.0006781341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9522923,0.01916198,0.002228141,0.0004490513,0.001621497,0.00004537232,0.000108802,0.0003680482,0.005624949,0.00008569677,0.0007160913,0.01729794],"study_design_scores_gemma":[0.8440756,0.148304,0.004842624,0.00003176023,0.0009870044,0.00004535793,0.00004082507,0.0003936244,0.0004840347,0.00011642,0.0006583651,0.00002041965],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880051,0.005989927,0.0005181809,0.0007663236,0.0003246747,0.002363937,0.0008251725,0.00007198295,0.001134627],"genre_scores_gemma":[0.9905048,0.001992505,0.001189518,0.001280726,0.0004257303,0.002616538,0.0009399757,0.00001819684,0.001031845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004399215,"threshold_uncertainty_score":0.02211785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03903562922247449,"score_gpt":0.3292918694018239,"score_spread":0.2902562401793494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}