{"id":"W2471681322","doi":"10.1111/hae.12952","title":"Efficacy and safety of BAY 81‐8973, a full‐length recombinant factor VIII: results from the LEOPOLD I trial","year":2016,"lang":"en","type":"article","venue":"Haemophilia","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bayer (Canada)","funders":"Bayer HealthCare; Bayer","keywords":"Medicine; Potency; Haemophilia A; Adverse effect; Clinical trial; Clinical endpoint; Quartile; Surgery; Internal medicine; Haemophilia; Confidence interval; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005198332,0.0002519772,0.0005536144,0.0000862001,0.0001594018,0.00001869333,0.00020837,0.0001871917,0.0003598538],"category_scores_gemma":[0.001323746,0.0001117104,0.000165444,0.0001894443,0.0003582546,0.00007696465,0.0001292483,0.0002430659,0.0001172688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008227812,"about_ca_system_score_gemma":0.000174065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000166106,"about_ca_topic_score_gemma":0.00005544366,"domain_scores_codex":[0.9977468,0.0001945386,0.0006002547,0.0004982279,0.0005368813,0.0004232616],"domain_scores_gemma":[0.9969089,0.00175739,0.0001485615,0.0008162498,0.000114112,0.0002548092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5185527,0.002519566,0.01385554,0.0001153531,0.001247998,0.0003293662,0.00385355,2.611069e-7,0.05589403,0.000728278,0.02130424,0.3815991],"study_design_scores_gemma":[0.5525504,0.008678192,0.3170023,0.001899064,0.0005409353,0.0000756628,0.000357275,0.00005521634,0.03373795,0.001844915,0.08253147,0.0007266441],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9769152,0.0004671677,0.00001064061,0.01869682,0.0005003977,0.001481977,0.0003604385,0.00005111697,0.001516236],"genre_scores_gemma":[0.9931149,0.00120094,0.0001217689,0.00008518143,0.0005682638,0.00002072572,0.00004998092,0.00003093741,0.004807295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3808725,"threshold_uncertainty_score":0.4555416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04992520799866522,"score_gpt":0.3105170020595251,"score_spread":0.2605917940608599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}