{"id":"W2471681322","doi":"10.1111/hae.12952","title":"Efficacy and safety of BAY 81‐8973, a full‐length recombinant factor VIII: results from the LEOPOLD I trial","year":2016,"lang":"en","type":"article","venue":"Haemophilia","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bayer (Canada)","funders":"Bayer HealthCare; Bayer","keywords":"Medicine; Potency; Haemophilia A; Adverse effect; Clinical trial; Clinical endpoint; Quartile; Surgery; Internal medicine; Haemophilia; Confidence interval; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00149757,0.0007791793,0.0011141,0.0001803133,0.0001933671,0.0009655314,0.0004684171,0.000795313,0.003872208],"category_scores_gemma":[0.00118673,0.000170092,0.0010863,0.000283632,0.0006023124,0.0006208988,0.0002102665,0.001678253,0.0008146872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007485642,"about_ca_system_score_gemma":0.0008335885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006999109,"about_ca_topic_score_gemma":0.001030641,"domain_scores_codex":[0.9993989,0.0002784067,0.0000449416,0.0001007988,0.00008360217,0.00009332439],"domain_scores_gemma":[0.9991328,0.0001894528,0.0003191747,0.00006405508,0.00006051989,0.0002339904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9000584,0.005832305,0.005727392,0.001067319,0.00195741,0.0001344534,0.0001326312,0.0006085649,0.007014215,0.0002624178,0.004228042,0.07297689],"study_design_scores_gemma":[0.737735,0.2191478,0.0313494,0.0002047816,0.002290667,0.0004000251,0.00007750368,0.0007925991,0.002849593,0.000315947,0.004797217,0.00003936823],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98415,0.008157277,0.0003218451,0.0005817195,0.00009867643,0.0006966525,0.002125732,0.00005705526,0.003811157],"genre_scores_gemma":[0.9896501,0.00342039,0.0003200756,0.0006971798,0.0001741381,0.0005118123,0.002989097,0.00002010872,0.002217012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003872208,"threshold_uncertainty_score":0.01295388,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04992520799866522,"score_gpt":0.3105170020595251,"score_spread":0.2605917940608599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}