{"id":"W2471687221","doi":"10.1021/acs.molpharmaceut.6b00428","title":"Radiolabeled B9958 Derivatives for Imaging Bradykinin B1 Receptor Expression with Positron Emission Tomography: Effect of the Radiolabel–Chelator Complex on Biodistribution and Tumor Uptake","year":2016,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Institute of Cancer Research; Canadian Institutes of Health Research; Arnold and Mabel Beckman Foundation","keywords":"Biodistribution; Chemistry; DOTA; Chelation; Bradykinin; In vitro; Imaging agent; In vivo; Peptide; Molecular biology; Receptor; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005747993,0.0006277831,0.0006490855,0.0001966422,0.0001339548,0.000440104,0.0005488919,0.0006492878,0.001096074],"category_scores_gemma":[0.0004038048,0.0004076746,0.0002111585,0.000291477,0.0001873757,0.0003446139,0.0003260834,0.0006755865,0.0004700681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005128664,"about_ca_system_score_gemma":0.0002193601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005914013,"about_ca_topic_score_gemma":0.001093934,"domain_scores_codex":[0.9996475,0.0001267364,0.00002433358,0.00007503159,0.00005912657,0.00006734665],"domain_scores_gemma":[0.9997974,0.00007738517,0.00004223299,0.00001983717,0.00002800568,0.00003522931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001480075,0.00002417236,0.00005915199,0.00004756837,0.000007823122,0.00002625642,0.00001202314,0.0001083097,0.9985991,0.00005567632,0.00004072077,0.0008711949],"study_design_scores_gemma":[0.00003936157,0.000242303,0.0004677647,0.000004683063,0.00001781987,0.0001468825,0.000008069544,0.001004631,0.9966703,0.00001227354,0.001378864,0.000007142276],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980838,0.003801056,0.01287678,0.0001920962,0.00003677265,0.0001772258,0.0002308527,0.0001081848,0.001739152],"genre_scores_gemma":[0.9445618,0.004251796,0.04476054,0.0002668827,0.00002539186,0.0003265475,0.001052872,0.000223186,0.004530892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001096074,"threshold_uncertainty_score":0.003721118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01363455205318369,"score_gpt":0.2855352343682718,"score_spread":0.2719006823150881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}