{"id":"W2471687221","doi":"10.1021/acs.molpharmaceut.6b00428","title":"Radiolabeled B9958 Derivatives for Imaging Bradykinin B1 Receptor Expression with Positron Emission Tomography: Effect of the Radiolabel–Chelator Complex on Biodistribution and Tumor Uptake","year":2016,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Institute of Cancer Research; Canadian Institutes of Health Research; Arnold and Mabel Beckman Foundation","keywords":"Biodistribution; Chemistry; DOTA; Chelation; Bradykinin; In vitro; Imaging agent; In vivo; Peptide; Molecular biology; Receptor; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003163238,0.0003232613,0.0004305604,0.0001089507,0.0002142595,0.0000226537,0.0001341937,0.00007087481,0.00002484756],"category_scores_gemma":[0.000162262,0.0001748847,0.0001843032,0.0002679827,0.0002416727,0.00009427281,0.00005408862,0.0001382298,0.000001205858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008042169,"about_ca_system_score_gemma":0.00006205801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003636213,"about_ca_topic_score_gemma":2.382397e-7,"domain_scores_codex":[0.9983501,0.0001931826,0.0003538658,0.0004056034,0.0003484293,0.0003488349],"domain_scores_gemma":[0.998789,0.0002782982,0.0002667243,0.0003383187,0.000132402,0.0001952416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001759772,0.0001057225,0.08286773,0.0001683211,0.000108156,0.000005795286,0.00008803755,0.00000304231,0.9005342,0.0001223546,0.0004127889,0.01382408],"study_design_scores_gemma":[0.00776053,0.0008252059,0.02741643,0.0009488261,0.0003111534,0.00004680445,0.00002082198,0.001004712,0.9566233,0.00003341819,0.004780121,0.0002286428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900077,0.002150018,0.004858337,0.0012856,0.0001352074,0.001326371,0.0001236387,0.00007031322,0.00004282951],"genre_scores_gemma":[0.9980813,0.00006222747,0.001159715,0.0003981964,0.00007554262,0.00004826817,0.00007269425,0.0000487588,0.00005331641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05608913,"threshold_uncertainty_score":0.713159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01363455205318369,"score_gpt":0.2855352343682718,"score_spread":0.2719006823150881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}