{"id":"W2471690778","doi":"10.1038/srep29389","title":"Peroxiredoxin 1 interacts with and blocks the redox factor APE1 from activating interleukin-8 expression","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Redox biology and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Canadian Institutes of Health Research","keywords":"Gene knockdown; Transcription factor; Cell biology; Downregulation and upregulation; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002627378,0.0001593413,0.0001228683,0.00003257093,0.0002809738,0.00009831003,0.0001609174,0.0001085948,0.00009113217],"category_scores_gemma":[0.0002899294,0.00007148275,0.00004311561,0.00006573934,0.0005369536,0.00001663405,0.0002137885,0.00008792006,0.00000310117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001032311,"about_ca_system_score_gemma":0.00005027692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001492897,"about_ca_topic_score_gemma":0.00003810511,"domain_scores_codex":[0.998575,0.00008679599,0.0002306212,0.0007339364,0.0001511541,0.0002225266],"domain_scores_gemma":[0.9988653,0.00006177607,0.0002363684,0.000666142,0.00009400304,0.00007643121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006711527,0.0000163308,0.01407034,0.000002015631,0.00002746988,0.00002091853,0.0002273182,4.524567e-7,0.9747161,0.000002168554,0.001842214,0.0090075],"study_design_scores_gemma":[0.0001783691,0.00008460763,0.007907488,0.0001154792,0.000005663707,0.00008071898,0.0002111771,0.000001723587,0.962975,0.0002432479,0.02806116,0.0001353862],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971438,0.0002279414,0.0006593078,0.000243958,0.0009828764,0.0001580217,0.00001314362,0.0000142336,0.0005567204],"genre_scores_gemma":[0.9964905,0.00001553255,0.0002925686,0.00004611096,0.0001351819,0.00001765081,0.0000513307,0.00001219462,0.002938872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02621895,"threshold_uncertainty_score":0.2914982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008810116805985516,"score_gpt":0.2386195910549948,"score_spread":0.2298094742490092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}