{"id":"W2471690778","doi":"10.1038/srep29389","title":"Peroxiredoxin 1 interacts with and blocks the redox factor APE1 from activating interleukin-8 expression","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Redox biology and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Canadian Institutes of Health Research","keywords":"Gene knockdown; Transcription factor; Cell biology; Downregulation and upregulation; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003087095,0.0003194176,0.0002618191,0.000103519,0.0001718807,0.0002943071,0.0002929413,0.0003067743,0.001226467],"category_scores_gemma":[0.0002207429,0.0001738562,0.0002173564,0.00007857758,0.0003222515,0.0003202333,0.0003083492,0.0008132972,0.000250989],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000194722,"about_ca_system_score_gemma":0.0001954069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001857725,"about_ca_topic_score_gemma":0.00021062,"domain_scores_codex":[0.9997061,0.00007312415,0.00002232654,0.00006995064,0.00005844962,0.00007017113],"domain_scores_gemma":[0.9998642,0.00003152717,0.00003856996,0.00002035982,0.00001204659,0.00003316736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001348193,0.00004401405,0.0001359344,0.00003786307,0.000005522044,0.00003911287,0.00001316271,0.00002321905,0.9986129,0.00015285,0.00003668628,0.0007639001],"study_design_scores_gemma":[0.00002108013,0.0002391496,0.001456839,0.000003970482,0.00001001137,0.0001782779,0.00001572265,0.0005289397,0.9958218,0.00005408115,0.001668082,0.000001981272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934308,0.001736275,0.003778215,0.0001636415,0.00004003943,0.00001204644,0.00005194718,0.00004896788,0.0007381233],"genre_scores_gemma":[0.9951209,0.0005685478,0.002007669,0.00004955135,0.00001314529,0.00002741715,0.0001905121,0.00001046871,0.002011644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001226467,"threshold_uncertainty_score":0.004102886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008810116805985516,"score_gpt":0.2386195910549948,"score_spread":0.2298094742490092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}