{"id":"W2471837641","doi":"10.18632/oncotarget.10446","title":"A novel isoflavone, ME-344, targets the cytoskeleton in acute myeloid leukemia","year":2016,"lang":"en","type":"article","venue":"Oncotarget","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of British Columbia; University Health Network","funders":"Fonds de Recherche du Québec - Santé; Stem Cell Network; MEI Pharma","keywords":"Myeloid leukemia; Microtubule polymerization; Tubulin; Leukemia; Cancer research; Cytotoxic T cell; Mechanism of action; Vinblastine; Apoptosis; Cell culture; Programmed cell death; Medicine; Microtubule; Haematopoiesis; Colchicine; Immunology; Biology; In vitro; Cell biology; Stem cell; Chemotherapy; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001115695,0.0002777287,0.0001975571,0.0002557361,0.0001948781,0.000221124,0.0001681494,0.0002176245,0.001433721],"category_scores_gemma":[0.00006742319,0.00009958092,0.0001948094,0.000204387,0.0001145673,0.0001789003,0.0001717563,0.0003622038,0.0003532438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002448241,"about_ca_system_score_gemma":0.0001335934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002658972,"about_ca_topic_score_gemma":0.0009698868,"domain_scores_codex":[0.9999561,0.000008806449,0.000003977016,0.000005379215,0.00001389672,0.00001179607],"domain_scores_gemma":[0.9999763,0.000003460163,0.000007333063,0.000001632085,0.000006038908,0.000005111215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004219869,0.0001114989,0.0008959251,0.0001638009,0.00001676529,0.00009995924,0.00001905414,0.0003679588,0.9786913,0.000192482,0.0005213977,0.01849777],"study_design_scores_gemma":[0.0002696397,0.004269977,0.01592502,0.00005571816,0.0001081438,0.00108835,0.0001390416,0.00233862,0.9460326,0.000354161,0.02940373,0.00001502453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834322,0.01107665,0.001406022,0.0006683315,0.00006038455,0.00005589646,0.000309111,0.00009539261,0.002896074],"genre_scores_gemma":[0.9857484,0.008503782,0.00199866,0.0001772836,0.00002776816,0.00003749794,0.0005349337,0.00001079206,0.002960858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001433721,"threshold_uncertainty_score":0.004796326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0164589339148734,"score_gpt":0.289835202970944,"score_spread":0.2733762690560706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}