{"id":"W2471837641","doi":"10.18632/oncotarget.10446","title":"A novel isoflavone, ME-344, targets the cytoskeleton in acute myeloid leukemia","year":2016,"lang":"en","type":"article","venue":"Oncotarget","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of British Columbia; University Health Network","funders":"Fonds de Recherche du Québec - Santé; Stem Cell Network; MEI Pharma","keywords":"Myeloid leukemia; Microtubule polymerization; Tubulin; Leukemia; Cancer research; Cytotoxic T cell; Mechanism of action; Vinblastine; Apoptosis; Cell culture; Programmed cell death; Medicine; Microtubule; Haematopoiesis; Colchicine; Immunology; Biology; In vitro; Cell biology; Stem cell; Chemotherapy; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000996701,0.0004028412,0.0006308701,0.0003102972,0.0001577666,0.00003835564,0.0006249042,0.0002960284,0.000858873],"category_scores_gemma":[0.0005276593,0.000213158,0.0002251572,0.0007401317,0.0003317316,0.0002644879,0.0003250412,0.0007998836,0.001352973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002425536,"about_ca_system_score_gemma":0.001471209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005669338,"about_ca_topic_score_gemma":0.0001979437,"domain_scores_codex":[0.9965903,0.0001267333,0.0005799818,0.0006996884,0.000868823,0.001134515],"domain_scores_gemma":[0.9977676,0.0004340719,0.0001389243,0.001099524,0.0001901131,0.0003697682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009506209,0.0002478011,0.03013269,0.0000579099,0.000275178,0.0004421737,0.00066139,0.000006122011,0.8526801,0.001039446,0.1055319,0.007974644],"study_design_scores_gemma":[0.02052375,0.001211718,0.258391,0.0006038474,0.0002474181,0.0008149145,0.0003959186,0.001231192,0.08904232,0.001271866,0.6251508,0.001115288],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9249795,0.0008351445,0.00430932,0.04918534,0.0004470927,0.001519818,0.0001113643,0.0002375778,0.01837485],"genre_scores_gemma":[0.9490131,0.001330494,0.006368836,0.00458853,0.0008789711,0.0002508945,0.00006414972,0.0001621054,0.03734298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7636378,"threshold_uncertainty_score":0.9994246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0164589339148734,"score_gpt":0.289835202970944,"score_spread":0.2733762690560706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}