{"id":"W2471903346","doi":"10.1186/s13075-016-1053-7","title":"H3K27me3 demethylases regulate in vitro chondrogenesis and chondrocyte activity in osteoarthritis","year":2016,"lang":"en","type":"article","venue":"Arthritis Research & Therapy","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Arthritis Research UK; Rosetrees Trust; Bayer HealthCare; Medical Research Council; Versus Arthritis; Ministero dello Sviluppo Economico; Ontario Ministry of Economic Development and Innovation; National Institute for Health and Care Research; Genome Canada; Wellcome Trust; GlaxoSmithKline; Pfizer; Eli Lilly and Company","keywords":"Chondrogenesis; Demethylase; Cartilage; Cell biology; Chemistry; Osteoarthritis; Mesenchymal stem cell; Chondrocyte; SOX9; Cancer research; Epigenetics; Gene expression; Biology; Biochemistry; Medicine; Anatomy; Pathology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002608785,0.0003244625,0.0002847375,0.0003159386,0.0001825538,0.0002544886,0.0002125837,0.0002352697,0.001829151],"category_scores_gemma":[0.0001805988,0.0001562283,0.0003465873,0.0002016399,0.0002776688,0.0001474848,0.0002133326,0.0003092884,0.0003937859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003008801,"about_ca_system_score_gemma":0.0002451048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00121841,"about_ca_topic_score_gemma":0.002641562,"domain_scores_codex":[0.9998803,0.00001766045,0.00001347689,0.00002192906,0.00003663911,0.00003004075],"domain_scores_gemma":[0.9998947,0.00002109529,0.0000334472,0.00001130039,0.0000210823,0.0000182874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002403902,0.00002041556,0.001024116,0.00008014348,0.00001799658,0.00002470956,0.00001028685,0.00008412672,0.9963657,0.00002452008,0.00004378708,0.002063726],"study_design_scores_gemma":[0.00002237249,0.0002421477,0.01611074,0.000006416106,0.00003410386,0.0001157166,0.00002555654,0.0002775906,0.9814801,0.00003322513,0.001647578,0.000004523923],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781602,0.01404085,0.004219361,0.0001377418,0.00005867446,0.00005829586,0.0009315975,0.0001137216,0.002279659],"genre_scores_gemma":[0.992676,0.002906526,0.001412152,0.00005602812,0.0000109563,0.00003161498,0.0007158057,0.00001469543,0.002176263],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001829151,"threshold_uncertainty_score":0.006119132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04316375451486368,"score_gpt":0.3281327279142348,"score_spread":0.2849689733993711,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}