{"id":"W2471958055","doi":"10.1128/mcb.00189-16","title":"Fibroblast Growth Factor Receptor-Dependent and -Independent Paracrine Signaling by Sunitinib-Resistant Renal Cell Carcinoma","year":2016,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Cancer Institute; National Institutes of Health; University of Texas Southwestern Medical Center; Cancer Prevention and Research Institute of Texas; American Cancer Society","keywords":"Sunitinib; Paracrine signalling; Cancer research; MAPK/ERK pathway; Biology; Fibroblast growth factor receptor; Angiogenesis; Fibroblast growth factor; Vascular endothelial growth factor; Platelet-derived growth factor receptor; Autocrine signalling; Growth factor; Signal transduction; Internal medicine; Cell biology; Receptor; Renal cell carcinoma; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002082654,0.0002301448,0.0005457191,0.0002413089,0.0001670859,0.0003905637,0.000120789,0.0001895397,0.0009244516],"category_scores_gemma":[0.0002329914,0.000108525,0.0003528876,0.0001852833,0.0001211389,0.0001225582,0.0001023142,0.0003002546,0.0002726569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003678372,"about_ca_system_score_gemma":0.0003776912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001339476,"about_ca_topic_score_gemma":0.002103619,"domain_scores_codex":[0.9997711,0.00003913389,0.00002620104,0.00004057245,0.00007684041,0.00004618467],"domain_scores_gemma":[0.9998673,0.00002842702,0.00002373088,0.00002319146,0.00002244728,0.00003487242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006348853,0.0001072687,0.008362831,0.00008438589,0.00004986086,0.0007899753,0.00007370966,0.000408018,0.9813071,0.0001178599,0.0002047159,0.007859377],"study_design_scores_gemma":[0.0001082778,0.002279803,0.1490802,0.00001524778,0.0001277368,0.01195073,0.0001845031,0.003934869,0.8236066,0.000134876,0.008545197,0.00003197261],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959579,0.002393204,0.0005455418,0.00003151128,0.00001017992,0.00002047696,0.0001596655,0.00002493109,0.0008564793],"genre_scores_gemma":[0.9983976,0.0005512011,0.0002581775,0.00001803223,0.000005125939,0.00001054157,0.0002886887,0.000004861058,0.0004657485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001339476,"threshold_uncertainty_score":0.003092527,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01064523847972621,"score_gpt":0.2163893790112006,"score_spread":0.2057441405314744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}