{"id":"W2472267260","doi":"10.1371/journal.pone.0158839","title":"Interleukin-6 Induces Vascular Endothelial Growth Factor-C Expression via Src-FAK-STAT3 Signaling in Lymphatic Endothelial Cells","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Lymphatic System and Diseases","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Landseed Hospital; Ministry of Science and Technology, Taiwan","keywords":"Lymphangiogenesis; Vascular endothelial growth factor; Focal adhesion; Vascular endothelial growth factor C; Cancer research; Signal transduction; Proto-oncogene tyrosine-protein kinase Src; Cell biology; STAT3; Lymphatic Endothelium; Gene knockdown; Biology; Vascular endothelial growth factor A; Chemistry; Molecular biology; Lymphatic system; Cell culture; Immunology; Metastasis; Cancer; VEGF receptors","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002053766,0.0003336521,0.0007105758,0.0002916509,0.000065787,0.0000381808,0.0002233575,0.0001537286,0.0008372614],"category_scores_gemma":[0.0004048386,0.000217973,0.0001904348,0.0001753689,0.00008205572,0.0002608245,0.00008810756,0.00003912297,0.0003450829],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000282014,"about_ca_system_score_gemma":0.0002110335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001261315,"about_ca_topic_score_gemma":0.0000057021,"domain_scores_codex":[0.9972622,0.0002024455,0.000637012,0.0005110763,0.0008830311,0.0005041719],"domain_scores_gemma":[0.9983602,0.0005324204,0.0001917604,0.0004492489,0.0001300936,0.0003362462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002774672,0.001678017,0.02462604,0.0005350743,0.0002343891,0.00009573351,0.0007442452,3.805655e-7,0.970498,0.00001564494,0.00003266529,0.001262303],"study_design_scores_gemma":[0.006659131,0.0002449239,0.002553105,0.004334226,0.0002852718,0.000008494759,0.0001744473,0.00003326473,0.985106,0.0002679804,0.0000348079,0.0002983342],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969359,0.0004529838,0.0005227903,0.0001215197,0.0001957849,0.0007914631,0.0001045698,0.0001367045,0.0007382692],"genre_scores_gemma":[0.997815,0.0001051417,0.000653371,0.0002219124,0.0006128717,0.0001052422,0.00001208371,0.00006743678,0.0004070092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02207293,"threshold_uncertainty_score":0.9167426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03429934784968,"score_gpt":0.2351373729939238,"score_spread":0.2008380251442438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}