{"id":"W2472642395","doi":"10.1016/j.nantod.2016.06.006","title":"Nanomedicine and tumor heterogeneity: Concept and complex reality","year":2016,"lang":"en","type":"article","venue":"Nano Today","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":82,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Ontario Institute for Cancer Research; University of Toronto","funders":"Canadian Institutes of Health Research; GlaxoSmithKline","keywords":"Nanomedicine; Nanocarriers; Drug delivery; Medicine; Drug; Tumor microenvironment; Computational biology; Nanotechnology; Pharmacology; Cancer research; Tumor cells; Biology; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002101362,0.000518098,0.0009551061,0.0008839415,0.0008436522,0.004116219,0.00149526,0.003177846,0.002057507],"category_scores_gemma":[0.00167644,0.0003204147,0.0003280215,0.0003447388,0.009447015,0.009943016,0.002075219,0.003182863,0.0003621579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001487051,"about_ca_system_score_gemma":0.0009197044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003713254,"about_ca_topic_score_gemma":0.0003567978,"domain_scores_codex":[0.999359,0.0002422722,0.00002458038,0.0001153762,0.0001885838,0.00007022775],"domain_scores_gemma":[0.9987997,0.0007651079,0.0001254404,0.0001054522,0.0001023347,0.0001019518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.00005806655,0.00009528596,0.000750641,0.0005872439,0.00003109315,0.0005364774,0.0007326293,0.001126765,0.02171928,0.9269804,0.00406927,0.04331289],"study_design_scores_gemma":[0.00005106505,0.0004584525,0.001179046,0.0002909589,0.00003954383,0.003767269,0.001568492,0.006176215,0.01819942,0.8222958,0.1458806,0.00009309792],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.08496423,0.4527802,0.2455466,0.1421924,0.004070847,0.000151134,0.0002189984,0.0002891315,0.0697865],"genre_scores_gemma":[0.8253943,0.09349492,0.04647232,0.01367787,0.007275247,0.0002815637,0.0001028264,0.0001051604,0.01319584],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004116219,"threshold_uncertainty_score":0.01111317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02846806205325269,"score_gpt":0.2702697065679112,"score_spread":0.2418016445146585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}