{"id":"W2472642395","doi":"10.1016/j.nantod.2016.06.006","title":"Nanomedicine and tumor heterogeneity: Concept and complex reality","year":2016,"lang":"en","type":"article","venue":"Nano Today","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":82,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Ontario Institute for Cancer Research; University of Toronto","funders":"Canadian Institutes of Health Research; GlaxoSmithKline","keywords":"Nanomedicine; Nanocarriers; Drug delivery; Medicine; Drug; Tumor microenvironment; Computational biology; Nanotechnology; Pharmacology; Cancer research; Tumor cells; Biology; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004748507,0.0001489944,0.0002553299,0.00004157262,0.0001156502,0.00004033317,0.0001244363,0.00004316267,0.0004799883],"category_scores_gemma":[0.0001157454,0.00009523823,0.00002196838,0.0000781983,0.0005106504,0.0001875628,0.0001361362,0.00003358014,0.0001104402],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004145178,"about_ca_system_score_gemma":0.00003710191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009477288,"about_ca_topic_score_gemma":0.00003330665,"domain_scores_codex":[0.9986556,0.0001300422,0.0002570875,0.00040201,0.0002288697,0.0003263822],"domain_scores_gemma":[0.9991375,0.000201585,0.00008741638,0.0003151006,0.00005885583,0.0001995398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004007282,0.00002711166,0.003064236,0.0000126835,0.000003923197,0.00001745569,0.0001057042,3.632547e-7,0.9909551,0.00028886,0.002101212,0.003383352],"study_design_scores_gemma":[0.001645089,0.0001831717,0.0180543,0.00006474872,0.0000197397,0.00005592264,0.00003178292,0.00002137501,0.9667301,0.0003163177,0.01267663,0.0002008745],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959478,0.0004321382,0.0002109,0.002607506,0.0002523943,0.0001780314,0.0000725456,0.00009227081,0.0002063935],"genre_scores_gemma":[0.9983784,0.0000289436,0.000383289,0.0008271253,0.0001029556,0.00001145059,0.000002438732,0.00001384664,0.000251583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02422498,"threshold_uncertainty_score":0.5255535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02846806205325269,"score_gpt":0.2702697065679112,"score_spread":0.2418016445146585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}