{"id":"W2472688469","doi":"10.1007/s00401-016-1585-6","title":"Towards authentic transgenic mouse models of heritable PrP prion diseases","year":2016,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"Creutzfeldt-Jakob Disease Foundation; National Institute on Aging; National Institutes of Health; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Sherman Fairchild Foundation","keywords":"Fatal familial insomnia; Mutant; Genetically modified mouse; Biology; Mutation; Transgene; Wild type; Phenotype; Neuropathology; Virology; Molecular biology; Disease; Genetics; Prion protein; Gene; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001018434,0.0001600918,0.0001716525,0.00003060434,0.00005824754,0.00001323228,0.0002896645,0.00009107713,0.00007999897],"category_scores_gemma":[0.0001504331,0.0001058399,0.0001684361,0.00006402064,0.00009698176,0.00001222521,0.0001313151,0.00004162777,0.000006234149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006668241,"about_ca_system_score_gemma":0.00005221876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002566024,"about_ca_topic_score_gemma":5.702288e-7,"domain_scores_codex":[0.9988742,0.0001325677,0.0002175272,0.0003824513,0.0001359314,0.0002572803],"domain_scores_gemma":[0.9992735,0.00001529099,0.00009822201,0.0004433187,0.00005517011,0.0001144497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001473843,0.0001128572,0.0005798797,0.00002580486,0.00001212084,0.000007815837,0.00001692586,0.00001506135,0.9774271,0.0001021384,0.0001634504,0.02138943],"study_design_scores_gemma":[0.001197244,0.001056459,0.01065502,0.00005766859,0.00009220363,0.0000234801,0.00002312001,0.00007667682,0.9746651,0.002346395,0.009351667,0.0004549436],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938084,0.002214142,0.003032876,0.0002696194,0.00006552899,0.000220902,0.0001247349,0.00003669064,0.0002271312],"genre_scores_gemma":[0.9950457,0.004039309,0.0002974058,0.0001512234,0.00005990918,0.00003001556,0.00001824165,0.00002439136,0.000333785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02093449,"threshold_uncertainty_score":0.4316027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01612762690170344,"score_gpt":0.2345959499055217,"score_spread":0.2184683230038183,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}