{"id":"W2472688469","doi":"10.1007/s00401-016-1585-6","title":"Towards authentic transgenic mouse models of heritable PrP prion diseases","year":2016,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"Creutzfeldt-Jakob Disease Foundation; National Institute on Aging; National Institutes of Health; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Sherman Fairchild Foundation","keywords":"Fatal familial insomnia; Mutant; Genetically modified mouse; Biology; Mutation; Transgene; Wild type; Phenotype; Neuropathology; Virology; Molecular biology; Disease; Genetics; Prion protein; Gene; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003064696,0.001122424,0.000692849,0.002299946,0.0006483801,0.001512118,0.001277891,0.001750233,0.003659888],"category_scores_gemma":[0.001733861,0.0008682221,0.0006226342,0.0007355834,0.001014234,0.001510293,0.0009542456,0.003429832,0.001943855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006305721,"about_ca_system_score_gemma":0.0004624588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003880657,"about_ca_topic_score_gemma":0.0007992419,"domain_scores_codex":[0.9983391,0.0004839355,0.000305693,0.0002414784,0.0004198476,0.0002099309],"domain_scores_gemma":[0.9982844,0.0004269999,0.0003608694,0.0003079962,0.0003548576,0.0002648286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002496444,0.0001904754,0.0002228293,0.00009633913,0.00001933582,0.0003194739,0.0001490876,0.0001848014,0.9914035,0.004856703,0.0003322089,0.001975607],"study_design_scores_gemma":[0.0002338276,0.0009765691,0.001688247,0.00008463176,0.0001956664,0.002404174,0.0001427622,0.003112707,0.962669,0.002624926,0.02582731,0.00004015615],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7285823,0.00626401,0.2433576,0.002493775,0.0009506532,0.001378503,0.004870624,0.002055619,0.01004688],"genre_scores_gemma":[0.8636532,0.009504859,0.09781736,0.0006349552,0.0002926659,0.00152094,0.006398766,0.0008750599,0.01930204],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003659888,"threshold_uncertainty_score":0.01620781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01612762690170344,"score_gpt":0.2345959499055217,"score_spread":0.2184683230038183,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}