{"id":"W2473240951","doi":"10.1186/s12864-016-2787-y","title":"Variants in ACPP are associated with cerebrospinal fluid Prostatic Acid Phosphatase levels","year":2016,"lang":"en","type":"article","venue":"BMC Genomics","topic":"Advanced Proteomics Techniques and Applications","field":"Chemistry","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, San Francisco; University of California, San Diego; National Institutes of Health; IXICO; Servier; University of California, Davis; Eisai; Genentech; Erasmus Medisch Centrum; Bundesministerium für Bildung und Forschung; Hjartavernd; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Pennsylvania; University of Southern California; Brigham Young University; Wellcome Trust; Synarc; National Heart, Lung, and Blood Institute; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health; Medpace; Brigham and Women's Hospital; Alzheimer's Disease Neuroimaging Initiative; Medical Research Council; Meso Scale Diagnostics","keywords":"Cerebrospinal fluid; Biology; Proteomics; Acid phosphatase; DNA microarray; Phosphatase; Prostatic acid phosphatase; Computational biology; Pathology; Biochemistry; Enzyme; Medicine; Gene; Neuroscience; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009765779,0.0007395401,0.0005701111,0.0009837183,0.0005469773,0.0009553432,0.0005485009,0.0008953097,0.003283581],"category_scores_gemma":[0.00369189,0.0003290671,0.0016389,0.002208652,0.0004053968,0.000294315,0.0005134637,0.0007181462,0.0002195323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002726988,"about_ca_system_score_gemma":0.0003537248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003993101,"about_ca_topic_score_gemma":0.003535643,"domain_scores_codex":[0.9990867,0.0001920768,0.0001254099,0.000353703,0.0001512772,0.00009076716],"domain_scores_gemma":[0.9972204,0.001308102,0.0009853592,0.0001787465,0.000148201,0.0001591263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002440242,0.0000674029,0.9622812,0.0002827222,0.00580369,0.001725005,0.0002227118,0.0008634148,0.01418316,0.0003404315,0.0008367737,0.01095333],"study_design_scores_gemma":[0.0001188053,0.0002264891,0.9839392,0.0001129206,0.00420353,0.003348184,0.0001473092,0.002016756,0.003175661,0.00110011,0.001584893,0.00002618621],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924513,0.003321666,0.001900095,0.0002785724,0.00004894759,0.00001124064,0.001286794,0.00007274207,0.000628561],"genre_scores_gemma":[0.9978763,0.0004867231,0.0008291952,0.00007303479,0.00003107491,0.00000944885,0.0004790162,0.00002073695,0.0001946271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003993101,"threshold_uncertainty_score":0.01098472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02384167038263264,"score_gpt":0.2582542572382605,"score_spread":0.2344125868556279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}