{"id":"W2473285660","doi":"10.3390/molecules21070841","title":"Synthesis and Evaluation of Ciprofloxacin-Nitroxide Conjugates as Anti-Biofilm Agents","year":2016,"lang":"en","type":"article","venue":"Molecules","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Institute for Future Environments, Queensland University of Technology; Fundación Ramón Areces; Australian Research Council; Centre for Blood Research, University of British Columbia; Queensland University of Technology; Asian Office of Aerospace Research and Development","keywords":"Nitroxide mediated radical polymerization; Biofilm; Antimicrobial; Combinatorial chemistry; Ciprofloxacin; Chemistry; Amine gas treating; Moiety; Reductive amination; Biocide; Microbiology; Biology; Bacteria; Antibiotics; Organic chemistry; Biochemistry; Radical polymerization; Polymer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002760034,0.000120164,0.0001400983,0.00003548654,0.00004270257,0.00001410182,0.00006694339,0.0001068369,0.00005516613],"category_scores_gemma":[0.0002808299,0.00008661851,0.00004913751,0.0000355025,0.0001095482,0.000004611657,0.00006889969,0.0000191701,0.00001051167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007356974,"about_ca_system_score_gemma":0.00004424598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002922083,"about_ca_topic_score_gemma":0.00000653076,"domain_scores_codex":[0.9991544,0.0001021549,0.0001710299,0.0002547484,0.0001578123,0.0001598187],"domain_scores_gemma":[0.9994866,0.00002077614,0.00009029327,0.0002093287,0.000139837,0.0000532078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000378056,0.00001857662,0.001497805,0.000009354545,0.00004259592,0.000001092009,0.00001092171,0.000001347444,0.9834316,0.00008742981,0.0001782177,0.01468321],"study_design_scores_gemma":[0.0004016179,0.00008900196,0.01138029,0.00005066927,0.00006110823,0.000006985347,0.0000249013,0.00002969305,0.9862603,0.00008033124,0.001487146,0.0001279705],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980992,0.0004081497,0.00003534372,0.0002559588,0.00008088414,0.000136639,0.00003011079,0.000007473241,0.0009462143],"genre_scores_gemma":[0.9992003,0.0002120547,0.0003195375,0.0000970875,0.00006215488,0.000007955408,0.0000149457,0.00001573725,0.0000702481],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01455524,"threshold_uncertainty_score":0.35322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01788582492435634,"score_gpt":0.2652062210994677,"score_spread":0.2473203961751114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}