{"id":"W2473285660","doi":"10.3390/molecules21070841","title":"Synthesis and Evaluation of Ciprofloxacin-Nitroxide Conjugates as Anti-Biofilm Agents","year":2016,"lang":"en","type":"article","venue":"Molecules","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Institute for Future Environments, Queensland University of Technology; Fundación Ramón Areces; Australian Research Council; Centre for Blood Research, University of British Columbia; Queensland University of Technology; Asian Office of Aerospace Research and Development","keywords":"Nitroxide mediated radical polymerization; Biofilm; Antimicrobial; Combinatorial chemistry; Ciprofloxacin; Chemistry; Amine gas treating; Moiety; Reductive amination; Biocide; Microbiology; Biology; Bacteria; Antibiotics; Organic chemistry; Biochemistry; Radical polymerization; Polymer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002037416,0.000323092,0.0002039261,0.0001688384,0.0001182867,0.0001526268,0.0001947468,0.0003488759,0.001137466],"category_scores_gemma":[0.0001948299,0.0001370336,0.0001377182,0.0001276313,0.0001241928,0.0002218223,0.0001300019,0.0002708564,0.0002590029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001916373,"about_ca_system_score_gemma":0.0001312931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002565511,"about_ca_topic_score_gemma":0.0007424339,"domain_scores_codex":[0.9998952,0.00002739542,0.00000902279,0.00002057576,0.00003077925,0.00001700634],"domain_scores_gemma":[0.9998828,0.00002241648,0.00003670009,0.000011219,0.00002602885,0.00002085842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004312922,0.00002807529,0.00004245125,0.00004837477,0.000004354875,0.00003186977,0.00001177716,0.0001153277,0.9979944,0.00005333153,0.00001367018,0.001613067],"study_design_scores_gemma":[0.00001979101,0.0009295375,0.0007466134,0.000005828416,0.00001508038,0.0001203644,0.000009160139,0.0003434063,0.9958807,0.00001350292,0.001909988,0.000005888926],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895083,0.002172101,0.006086308,0.00005851263,0.00002024421,0.0001427133,0.0001870889,0.00004642404,0.001778193],"genre_scores_gemma":[0.9810454,0.001633543,0.01426582,0.00003489095,0.00001101061,0.0001188379,0.0002461357,0.00001471765,0.002629698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001137466,"threshold_uncertainty_score":0.00380522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01788582492435634,"score_gpt":0.2652062210994677,"score_spread":0.2473203961751114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}