{"id":"W2473420009","doi":"10.1200/jco.2014.32.15_suppl.3514","title":"Phase I study of the selective BRAF<sup>V600 </sup>inhibitor encorafenib (LGX818) combined with cetuximab and with or without the α-specific PI3K inhibitor BYL719 in patients with advanced <i>BRAF</i>-mutant colorectal cancer.","year":2014,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Princess Margaret Cancer Centre","funders":"","keywords":"Cetuximab; Medicine; Tolerability; Pharmacology; Vomiting; Internal medicine; Oncology; Colorectal cancer; Cancer; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001041666,0.0004013808,0.002373736,0.0001145574,0.000215132,0.00002015673,0.0002404876,0.000174552,0.00001999597],"category_scores_gemma":[0.0004704787,0.0001508818,0.0001524167,0.000605966,0.0008661611,0.00016514,0.0001100214,0.001133583,5.25844e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003641143,"about_ca_system_score_gemma":0.00133385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009649771,"about_ca_topic_score_gemma":0.003475199,"domain_scores_codex":[0.9959052,0.0007425688,0.001652982,0.000461979,0.0008367497,0.0004005629],"domain_scores_gemma":[0.9950707,0.001526839,0.001909081,0.0002983143,0.0009480307,0.000247062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2148699,0.01823924,0.72373,0.0000289579,0.001107407,0.0001172171,0.0041733,0.0001127428,0.00006287111,0.000005708105,0.0002206845,0.03733201],"study_design_scores_gemma":[0.1363272,0.3492564,0.5079626,0.0003871775,0.0007787945,0.0001084922,0.00345594,0.00008399496,0.0002319033,0.000009744683,0.001202057,0.0001956878],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995411,0.0002336658,0.00001027143,0.001352305,0.0003616426,0.002289963,0.00001560076,0.0000117623,0.0003137622],"genre_scores_gemma":[0.9985641,0.0001732274,0.000249946,0.0004191619,0.0003818329,0.0001073744,0.00000171768,0.00004279339,0.00005987407],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3310171,"threshold_uncertainty_score":0.6152779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03056508449280592,"score_gpt":0.3714473643200866,"score_spread":0.3408822798272806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}