{"id":"W2473581189","doi":"10.1093/annonc/mdv532.60","title":"476TiP Phase II study of BI1482694 in patients (pts) with T790M-positive non-small cell lung cancer (NSCLC) after treatment with an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI)","year":2015,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Medicine; T790M; Epidermal growth factor receptor; Tyrosine kinase; Tyrosine-kinase inhibitor; Lung cancer; Internal medicine; Oncology; Cancer research; Phases of clinical research; Cancer; Receptor; Chemotherapy; Gefitinib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008110575,0.001852208,0.003368043,0.000503642,0.0003535062,0.001346471,0.001214051,0.001510742,0.006406507],"category_scores_gemma":[0.0006202831,0.0007855903,0.001954734,0.0005759156,0.0008517741,0.0008412304,0.0005058209,0.004968936,0.002776407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000791061,"about_ca_system_score_gemma":0.001554309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001661286,"about_ca_topic_score_gemma":0.003555774,"domain_scores_codex":[0.9996381,0.0001457219,0.00001690599,0.00005462738,0.00002972986,0.0001149479],"domain_scores_gemma":[0.9995765,0.00004771803,0.00005698706,0.00003142093,0.00002641964,0.0002609009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8117498,0.04310734,0.006181402,0.0007025898,0.002138982,0.0003128295,0.0001798348,0.002410943,0.03603376,0.0003397689,0.00861063,0.08823228],"study_design_scores_gemma":[0.714291,0.2675866,0.01073773,0.00003203665,0.0006989195,0.0002257426,0.00004919025,0.001115694,0.002213363,0.0001456967,0.002862853,0.00004115915],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879587,0.002216984,0.0006285493,0.0007627543,0.0002770003,0.001966611,0.00266838,0.0002893783,0.003231643],"genre_scores_gemma":[0.9707295,0.003597818,0.001980823,0.002068715,0.0003493479,0.003369057,0.01068845,0.00012117,0.00709517],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006406507,"threshold_uncertainty_score":0.02143192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03907887348498267,"score_gpt":0.3792393443305347,"score_spread":0.340160470845552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}