{"id":"W2473677923","doi":"10.1593/neo.06472","title":"Ubiquitin-Dependent Regulation of TGβ Signaling in Cancer","year":2006,"lang":"en","type":"review","venue":"Neoplasia","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"SMAD; Signal transduction; Biology; Cell biology; Ubiquitin; Carcinogenesis; Angiogenesis; Transforming growth factor; BMPR2; Cancer; Cancer research; Bone morphogenetic protein; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003979173,0.0008448577,0.001072573,0.001481759,0.0003144973,0.0007654736,0.000840764,0.001011086,0.003009435],"category_scores_gemma":[0.0002565843,0.0002438242,0.0002666324,0.001592999,0.0004086749,0.0009494197,0.0005837891,0.001080972,0.004185087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007309786,"about_ca_system_score_gemma":0.0005867858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008298213,"about_ca_topic_score_gemma":0.001500547,"domain_scores_codex":[0.9999013,0.0000170269,0.0000117762,0.00001771176,0.00003880738,0.00001327675],"domain_scores_gemma":[0.9998989,0.00002409055,0.00001738034,0.000005650486,0.00003297118,0.00002092161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009929842,0.00006375818,0.0001920423,0.006077747,0.00005733665,0.0003855228,0.00005565708,0.0004025112,0.004591438,0.003791936,0.0312678,0.953015],"study_design_scores_gemma":[0.0000190095,0.00005919173,0.0006944961,0.0007041958,0.00003585609,0.001319444,0.0000284047,0.00006012226,0.001041309,0.001420279,0.9946075,0.000010256],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002165125,0.9977349,0.0001772051,0.0001644497,0.0001686814,0.00000530509,0.00001412446,0.00001211383,0.001506745],"genre_scores_gemma":[0.00116382,0.9968741,0.0002150424,0.0001344371,0.0001049713,0.000008098342,0.00003281681,0.000001630823,0.001465048],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003009435,"threshold_uncertainty_score":0.01006758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02848246468796743,"score_gpt":0.331541027185508,"score_spread":0.3030585624975406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}