{"id":"W2473766466","doi":"10.1007/978-1-62703-011-3_8","title":"Engineering of Large Deletions and Duplications In Vivo","year":2012,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Limiting; Subcloning; Biology; Insertional mutagenesis; Transgene; Gene; Computational biology; Genetics; Stem cell; Cell biology; Genome; Engineering; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000667131,0.000679956,0.0005491527,0.0004892221,0.0002129625,0.0003648766,0.0006531358,0.0007110084,0.002021274],"category_scores_gemma":[0.0005329567,0.0006094388,0.0004619316,0.0002797174,0.0003837356,0.0003113505,0.0007912729,0.001017033,0.001495012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000195585,"about_ca_system_score_gemma":0.0003079268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001441944,"about_ca_topic_score_gemma":0.0003204675,"domain_scores_codex":[0.999534,0.0001149542,0.00006491697,0.0001177876,0.0001119472,0.00005627114],"domain_scores_gemma":[0.9992879,0.0002504817,0.0001940852,0.0001520841,0.00003665682,0.00007876886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003376615,0.0000192135,0.00006710859,0.00006362821,0.000008718417,0.0001356902,0.00002447427,0.0003349397,0.9962907,0.0005706445,0.00006371117,0.002387518],"study_design_scores_gemma":[0.00002950144,0.0001776045,0.0006796751,0.00001651677,0.00003600187,0.001014644,0.00001835819,0.001172338,0.9847413,0.0002322163,0.01187212,0.00000981198],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.64591,0.001762313,0.3414185,0.0003478557,0.0002627436,0.0006691316,0.002732118,0.001684343,0.005212974],"genre_scores_gemma":[0.8209622,0.003946396,0.1547701,0.0001896256,0.00007948042,0.0006576694,0.004288678,0.0008611042,0.01424475],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.002021274,"threshold_uncertainty_score":0.006761849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01245806183391213,"score_gpt":0.3524242433366908,"score_spread":0.3399661815027786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}