{"id":"W2473812116","doi":"10.1021/acs.biochem.6b00460","title":"Conformational Dynamics and the Binding of Specific and Nonspecific DNA by the Autoinhibited Transcription Factor Ets-1","year":2016,"lang":"en","type":"article","venue":"Biochemistry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Huntsman Cancer Institute; National Institute of General Medical Sciences; Huntsman Cancer Foundation; Howard Hughes Medical Institute","keywords":"DNA; Chemistry; DNA-binding domain; Hydrogen bond; Biophysics; Helix (gastropod); Transcription factor; Crystallography; Molecular dynamics; Binding selectivity; Conformational change; Nuclear magnetic resonance spectroscopy; Binding site; Transcription (linguistics); Protein structure; DNA-binding protein; Stereochemistry; Biochemistry; Molecule; Biology; Gene; Computational chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001418373,0.0001665243,0.0001562174,0.00007332816,0.0001341866,0.0002063518,0.0003123927,0.0001742267,0.0005867237],"category_scores_gemma":[0.0003177195,0.0001499616,0.0001061342,0.00007581079,0.0002173999,0.0002505109,0.0002026128,0.0003386707,0.0001612163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003097116,"about_ca_system_score_gemma":0.0001021632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005919924,"about_ca_topic_score_gemma":0.001052511,"domain_scores_codex":[0.9999006,0.00001620192,0.00000374435,0.00002534918,0.00003085315,0.00002327996],"domain_scores_gemma":[0.9998584,0.00004803736,0.00003900269,0.00001067931,0.0000139571,0.00002990768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009936727,0.00002927472,0.0008447873,0.00001562525,0.000009442514,0.00003491074,0.00005061567,0.0007653789,0.9971692,0.0001436144,0.00002062205,0.0008171691],"study_design_scores_gemma":[0.00002767361,0.0003262375,0.03180218,0.000008223637,0.00002482435,0.0002195384,0.0001748065,0.03076063,0.9354099,0.000304526,0.0009147162,0.00002664891],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994117,0.00007784315,0.0003123764,0.000008397941,0.000001195463,0.000001069368,0.00001168215,0.000004168056,0.0001715465],"genre_scores_gemma":[0.9992157,0.00009914396,0.0002741915,0.00001397587,0.000001821074,0.000004633735,0.00006797377,0.000005436826,0.0003170471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005919924,"threshold_uncertainty_score":0.002247095,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005452321764469956,"score_gpt":0.1918233782570277,"score_spread":0.1863710564925578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}