{"id":"W2474322740","doi":"10.1007/978-1-4939-3299-3_14","title":"Methods in the Study of PTEN Structure: X-Ray Crystallography and Hydrogen Deuterium Exchange Mass Spectrometry","year":2015,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Victoria","funders":"","keywords":"Hydrogen–deuterium exchange; PTEN; Mass spectrometry; Chemistry; Biophysics; Deuterium; Phosphorylation; Membrane; Crystallography; Biochemistry; Biology; Chromatography; Signal transduction; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00292749,0.001196775,0.000961566,0.001231176,0.0007379583,0.0009197202,0.00157818,0.0007826664,0.001836175],"category_scores_gemma":[0.001368844,0.0008250794,0.0006103899,0.001559015,0.001016456,0.001107568,0.0009515446,0.002882015,0.0008925883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008469611,"about_ca_system_score_gemma":0.001363457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002260457,"about_ca_topic_score_gemma":0.002544303,"domain_scores_codex":[0.9992035,0.0002419757,0.0000496248,0.0001081523,0.0003300837,0.00006670758],"domain_scores_gemma":[0.9994186,0.0001966959,0.00008615591,0.0001542504,0.00009486428,0.00004950415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000620581,0.0005338658,0.002748994,0.002119745,0.0003470224,0.0004588277,0.0003098532,0.007325808,0.8265957,0.05191251,0.01569132,0.09133575],"study_design_scores_gemma":[0.000434241,0.0003647447,0.006429548,0.0001640398,0.0001696029,0.001857229,0.0002363261,0.04710036,0.8102466,0.02382377,0.1089847,0.0001887797],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.1055814,0.03051399,0.8405347,0.005720492,0.0009054761,0.0005263943,0.003357635,0.001719439,0.01114052],"genre_scores_gemma":[0.2722682,0.043554,0.6714672,0.001072077,0.0002807166,0.0006860024,0.004301401,0.0004647141,0.005905809],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.00292749,"threshold_uncertainty_score":0.01548225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03061697368454208,"score_gpt":0.3951603977850663,"score_spread":0.3645434241005242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}